Clinical Interventions in Aging (Apr 2021)
Glomerular Filtration Dysfunction is Associated with Cardiac Adverse Remodeling in Menopausal Diabetic Chinese Women
Abstract
Xing Song,1 Gang Li,1 Yuqi Zhu,1 Jari A Laukkanen2– 4 1Division of Cardiology, Department of Geriatrics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of China; 2Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland; 3Institute of Clinical Medicine, Department of Medicine, University of Eastern Finland, Kuopio, Finland; 4Central Finland Health Care District, Department of Medicine, Jyväskylä, FinlandCorrespondence: Gang LiDivision of Cardiology, Department of Geriatrics, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Road, Yuzhong District, Chongqing, 400016, People’s Republic of ChinaTel +86 23 89011518Fax +86 23 68811487Email [email protected]: Previous studies have showed that nephropathy was associated with cardiac structural changes and dysfunction among diabetic adults. However, information on the association of glomerular filtration dysfunction with the cardiac adverse remodeling is still limited in menopausal diabetic women. Therefore, we investigated whether impaired glomerular filtration function is associated with the cardiac adverse remodeling in menopausal Chinese women with type 2 diabetes mellitus (DM).Methods: A total of 1231 hospitalized menopausal Chinese women with type 2 DM were collected retrospectively. The cross-sectional data of echocardiography were compared among estimated glomerular filtration rate (eGFR) categorized groups.Results: In menopausal diabetic women, moderate to severe glomerular filtration dysfunction (eGFR < 60 mL/min per 1.73m2) was found to be associated with enlarged left-side atrioventricular chambers, increased ventricular wall thickness, decreased cardiac function and dilated right ventricle (All P < 0.05).Conclusion: Glomerular filtration dysfunction is associated with cardiac adverse structural remodeling and dysfunction in menopausal Chinese women with type 2 DM.Keywords: glomerular filtration rate, type 2 diabetes mellitus, cardiac remodeling, menopausal women, aging
