BONE MINERAL DENSITY IN YOUNG FEMALES WITH JUVENILE IDIOPATHIC ARTHRITIS

Abstract

Background: bone mineral density (BMD) in young adults with juvenile idiopathic arthritis (JIA) is affected by the presence of chronic systemic inflammation and the administration of glucocorticoids. Objective: the study of BMD in young adult females with JIA. Material and methods: 99 females aged 19-39 years were divided into two groups: group І – 59 healthy young females, group ІІ – 40 young females with JIA. BMD in different areas and their T- and Z-scores were evaluated by the X-ray densitometry. Results: the age of JIA onset was 11.16 ± 4.34 years, the disease duration averaged 11.9 ± 9.4 years. BMD, T- and Z-scores at L1-L4 (p <0.001), BMD and T-score (p <0.001) in the femoral neck (FN), BMD, T- and Z-scores (p <0.001) in the total body (TB) in group II were lower than in group I. In group II Z-score <-2 SD was detected in 40% of patients at L1-L4, in 24% of patients in the FN, in 35.5% – in the TB and in 52.9% – in the ultradistal forearm (UDF), and T-score <-2.5 SD was found in 3.3% of patients at L1-L4, in 3.4% – in the FN, in 36.7% – in the TB, in 23.5% – in the UDF. Conclusions: The presence of JIA in childhood negatively affects the formation of peak bone mass and leads to a decrease in the BMD, T- and Z-scores at L1-L4, in the FN and TB in adulthood compared to healthy women of the corresponding age.

Keywords

• juvenile idiopathic arthritis
• bone mineral density
• young females
• T-score
• Z-score
• osteoporosis
• osteopenia