O-GlcNAcylation Modification in Immune Cells: Potential Therapeutic Implications of Sepsis

Abstract

Abstract O-GlcNAc modification is a glycosylation modification that is commonly observed in nuclear and organelle proteins of cells. In recent years, several studies have shown that O-GlcNAc modification plays an important regulatory role in immune cells, which regulates their activity and function and inhibits inflammatory responses. It also enhances immune cells recognition and clearance of pathogens, and improves the host´s antibacterial immune response. Sepsis is a systemic inflammatory response to infection, whose development and progression are regulated by the immune system. Therefore, in the present review, we will discuss the mechanism of O-GlcNAc modification in immune cells and its potential therapeutic value in sepsis, which will be expected to provide new insights and targets for the treatment of sepsis.

Keywords

• O-GlcNAcylation modification
• Immune cells
• Sepsis
• Inflammation