SYSTEM OF MATRIX METALLOPROTEINASES IN THE EVALUATION OF LUNG TISSUE DESTRUCTION IN TUBERCULOSIS

Abstract

New untreated infiltrate pulmonary tuberculosis patients commonly demonstrated the same referent level of MMP-8, MMP-3 and multiple increase of MMP-9 level on the background of diverse changes of inhibiting potential (retaining the reference level of TIMP-1 and reduced α2 -МG). Destructive process is related to unbalanced increase of рro-ММР-1 and ММР-9. At the same time the level of рro-ММР-1 correlates to changes in ROF, activity of proteinases of other classes (serine proteinases) and depends on the dissemination of the disease, while the changes in MMP-9 level are influenced by the massiveness of bacillary excretion.

Keywords

• туберкулез
• матриксные металлопротеиназы
• экстрацеллюлярный матрикс