A New and Efficient Method for the Synthesis of 3,4-Disubstituted Pyrrolidine-2,5-diones

Abstract

A newly found reaction for the synthesis of 3,4-disubstituted 1-hydroxy-pyrrolidine-2,5-diones from 3-substituted coumarins and nitromethane has been elaborated. The reaction involved a simple and convenient experimental procedure. The applicability of the rearrangement reaction is determined.

Keywords

• pyrrolidine-2,5-dione
• pyrrolidine
• 3-substituted coumarins
• 2-oxo-2<em>Н</em>-1-benzopyrane
• Michael addition reaction
• rearrangement
• Nef reaction