Biological characteristics of γδT cells and application in tumor immunotherapy

Renhong Zhu; Renhong Zhu; Qian Yan; Yashu Wang; Keqiang Wang

doi:10.3389/fgene.2022.1077419

Frontiers in Genetics (Jan 2023)

Biological characteristics of γδT cells and application in tumor immunotherapy

Renhong Zhu,
Renhong Zhu,
Qian Yan,
Yashu Wang,
Keqiang Wang

Affiliations

Renhong Zhu: Department of Laboratory Medicine, Second Affiliated Hospital of Shandong First Medical University, Tai’an, China
Renhong Zhu: Department of Laboratory Medicine, Tai’an Tumor Prevention and Treatment Hospital, Tai’an, China
Qian Yan: Department of Laboratory Medicine, Second Hospital of Traditional Chinese Medicine, Tai’an, China
Yashu Wang: Department of Laboratory Medicine, The Affiliated Tai’an City Central Hospital of Qingdao University, Tai’an, China
Keqiang Wang: Department of Laboratory Medicine, Second Affiliated Hospital of Shandong First Medical University, Tai’an, China

DOI: https://doi.org/10.3389/fgene.2022.1077419
Journal volume & issue: Vol. 13

Abstract

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Human γδT cells are a special immune cell type which exist in small quantities in the body, do not require processing and presentation for antigen recognition, and have non-major histocompatibility complex (MHC)-restricted immune response. They play an important role in the body’s anti-tumor, anti-infection, immune regulation, immune surveillance and maintenance of immune tolerance. This article reviews the generation and development of human γδT cells, genetic characteristics, classification, recognition and role of antigens, and research progress in tumor immunotherapy.

Published in Frontiers in Genetics

ISSN: 1664-8021 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Biology (General): Genetics
Website: http://journal.frontiersin.org/journal/genetics

About the journal

Abstract

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