Communications Biology (Mar 2022)
Antibody-dependent enhancement (ADE) of SARS-CoV-2 pseudoviral infection requires FcγRIIB and virus-antibody complex with bivalent interaction
- Shuang Wang,
- Junchao Wang,
- Xiaojuan Yu,
- Wen Jiang,
- Shuo Chen,
- Rongjuan Wang,
- Mingzhu Wang,
- Shasha Jiao,
- Yingying Yang,
- Wenbo Wang,
- Huilin Chen,
- Ben Chen,
- Chunying Gu,
- Chuang Liu,
- An Wang,
- Min Wang,
- Gang Li,
- Cuicui Guo,
- Datao Liu,
- Jinchao Zhang,
- Min Zhang,
- Lan Wang,
- Xun Gui
Affiliations
- Shuang Wang
- Mabwell (Shanghai) Bioscience Co., Ltd
- Junchao Wang
- School of Life Sciences, Anhui University
- Xiaojuan Yu
- Key Laboratory of the Ministry of Health for Research on Quality and Standardization of Biotech Products, National Institutes for Food and Drug Control
- Wen Jiang
- Mabwell (Shanghai) Bioscience Co., Ltd
- Shuo Chen
- Ludwig Cancer Research, Nuffield Department of Medicine, University of Oxford
- Rongjuan Wang
- Mabwell (Shanghai) Bioscience Co., Ltd
- Mingzhu Wang
- School of Life Sciences, Anhui University
- Shasha Jiao
- Mabwell (Shanghai) Bioscience Co., Ltd
- Yingying Yang
- Mabwell (Shanghai) Bioscience Co., Ltd
- Wenbo Wang
- Key Laboratory of the Ministry of Health for Research on Quality and Standardization of Biotech Products, National Institutes for Food and Drug Control
- Huilin Chen
- Mabwell (Shanghai) Bioscience Co., Ltd
- Ben Chen
- Mabwell (Shanghai) Bioscience Co., Ltd
- Chunying Gu
- Mabwell (Shanghai) Bioscience Co., Ltd
- Chuang Liu
- Mabwell (Shanghai) Bioscience Co., Ltd
- An Wang
- Mabwell (Shanghai) Bioscience Co., Ltd
- Min Wang
- Mabwell (Shanghai) Bioscience Co., Ltd
- Gang Li
- Mabwell (Shanghai) Bioscience Co., Ltd
- Cuicui Guo
- Mabwell (Shanghai) Bioscience Co., Ltd
- Datao Liu
- Mabwell (Shanghai) Bioscience Co., Ltd
- Jinchao Zhang
- Mabwell (Shanghai) Bioscience Co., Ltd
- Min Zhang
- School of Life Sciences, Anhui University
- Lan Wang
- Key Laboratory of the Ministry of Health for Research on Quality and Standardization of Biotech Products, National Institutes for Food and Drug Control
- Xun Gui
- Mabwell (Shanghai) Bioscience Co., Ltd
- DOI
- https://doi.org/10.1038/s42003-022-03207-0
- Journal volume & issue
-
Vol. 5,
no. 1
pp. 1 – 9
Abstract
By distinguishing between two types of neutralizing antibodies that either exhibit or lack antibody-dependent enhancement (ADE) activity, FcγRIIB and bivalent binding are shown to be required for ADE in SARS-CoV-2 infection.
