Nature Communications (Mar 2018)
Structure of Schlafen13 reveals a new class of tRNA/rRNA- targeting RNase engaged in translational control
- Jin-Yu Yang,
- Xiang-Yu Deng,
- Yi-Sheng Li,
- Xian-Cai Ma,
- Jian-Xiong Feng,
- Bing Yu,
- Yang Chen,
- Yi-Ling Luo,
- Xi Wang,
- Mei-Ling Chen,
- Zhi-Xin Fang,
- Fu-Xiang Zheng,
- Yi-Ping Li,
- Qian Zhong,
- Tie-Bang Kang,
- Li-Bing Song,
- Rui-Hua Xu,
- Mu-Sheng Zeng,
- Wei Chen,
- Hui Zhang,
- Wei Xie,
- Song Gao
Affiliations
- Jin-Yu Yang
- State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center
- Xiang-Yu Deng
- State Key Laboratory for Biocontrol, School of Life Sciences, Sun Yat-Sen University
- Yi-Sheng Li
- Laboratory for Functional Genomics and Systems Biology, Berlin Institute for Medical Systems Biology
- Xian-Cai Ma
- Key Laboratory of Tropical Disease Control of Ministry of Education, Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-Sen University
- Jian-Xiong Feng
- State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center
- Bing Yu
- State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center
- Yang Chen
- State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center
- Yi-Ling Luo
- State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center
- Xi Wang
- Laboratory for Functional Genomics and Systems Biology, Berlin Institute for Medical Systems Biology
- Mei-Ling Chen
- State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center
- Zhi-Xin Fang
- State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center
- Fu-Xiang Zheng
- Key Laboratory of Tropical Disease Control of Ministry of Education, Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-Sen University
- Yi-Ping Li
- Key Laboratory of Tropical Disease Control of Ministry of Education, Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-Sen University
- Qian Zhong
- State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center
- Tie-Bang Kang
- State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center
- Li-Bing Song
- State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center
- Rui-Hua Xu
- State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center
- Mu-Sheng Zeng
- State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center
- Wei Chen
- Department of Biology, Southern University of Science and Technology
- Hui Zhang
- Key Laboratory of Tropical Disease Control of Ministry of Education, Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-Sen University
- Wei Xie
- State Key Laboratory for Biocontrol, School of Life Sciences, Sun Yat-Sen University
- Song Gao
- State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center
- DOI
- https://doi.org/10.1038/s41467-018-03544-x
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 13
Abstract
Translation inhibition is a strategy for organisms to overcome various environmental stresses including viral infections. Here the authors show that a tRNA/rRNA-targeting RNase Schlafen13 inhibits protein synthesis by directly digesting cytoplasmic tRNA and rRNA with the ability to restrict viral propagation.
