Nature Communications (Jun 2021)
Mapping chromatin accessibility and active regulatory elements reveals pathological mechanisms in human gliomas
- Karolina Stępniak,
- Magdalena A. Machnicka,
- Jakub Mieczkowski,
- Anna Macioszek,
- Bartosz Wojtaś,
- Bartłomiej Gielniewski,
- Katarzyna Poleszak,
- Malgorzata Perycz,
- Sylwia K. Król,
- Rafał Guzik,
- Michał J. Dąbrowski,
- Michał Dramiński,
- Marta Jardanowska,
- Ilona Grabowicz,
- Agata Dziedzic,
- Hanna Kranas,
- Karolina Sienkiewicz,
- Klev Diamanti,
- Katarzyna Kotulska,
- Wiesława Grajkowska,
- Marcin Roszkowski,
- Tomasz Czernicki,
- Andrzej Marchel,
- Jan Komorowski,
- Bozena Kaminska,
- Bartek Wilczyński
Affiliations
- Karolina Stępniak
- Nencki Institute of Experimental Biology of the Polish Academy of Sciences
- Magdalena A. Machnicka
- Faculty of Mathematics, Informatics and Mechanics, University of Warsaw
- Jakub Mieczkowski
- Nencki Institute of Experimental Biology of the Polish Academy of Sciences
- Anna Macioszek
- Faculty of Mathematics, Informatics and Mechanics, University of Warsaw
- Bartosz Wojtaś
- Nencki Institute of Experimental Biology of the Polish Academy of Sciences
- Bartłomiej Gielniewski
- Nencki Institute of Experimental Biology of the Polish Academy of Sciences
- Katarzyna Poleszak
- Nencki Institute of Experimental Biology of the Polish Academy of Sciences
- Malgorzata Perycz
- Nencki Institute of Experimental Biology of the Polish Academy of Sciences
- Sylwia K. Król
- Nencki Institute of Experimental Biology of the Polish Academy of Sciences
- Rafał Guzik
- Nencki Institute of Experimental Biology of the Polish Academy of Sciences
- Michał J. Dąbrowski
- Institute of Computer Science of the Polish Academy of Sciences
- Michał Dramiński
- Institute of Computer Science of the Polish Academy of Sciences
- Marta Jardanowska
- Institute of Computer Science of the Polish Academy of Sciences
- Ilona Grabowicz
- Institute of Computer Science of the Polish Academy of Sciences
- Agata Dziedzic
- Institute of Computer Science of the Polish Academy of Sciences
- Hanna Kranas
- Faculty of Mathematics, Informatics and Mechanics, University of Warsaw
- Karolina Sienkiewicz
- Faculty of Mathematics, Informatics and Mechanics, University of Warsaw
- Klev Diamanti
- Department of Cell and Molecular Biology, Uppsala University
- Katarzyna Kotulska
- Departments of Neurology, Neurosurgery, Neuropathology, The Children’s Memorial Health Institute
- Wiesława Grajkowska
- Departments of Neurology, Neurosurgery, Neuropathology, The Children’s Memorial Health Institute
- Marcin Roszkowski
- Departments of Neurology, Neurosurgery, Neuropathology, The Children’s Memorial Health Institute
- Tomasz Czernicki
- Department of Neurosurgery, Medical University of Warsaw
- Andrzej Marchel
- Department of Neurosurgery, Medical University of Warsaw
- Jan Komorowski
- Department of Cell and Molecular Biology, Uppsala University
- Bozena Kaminska
- Nencki Institute of Experimental Biology of the Polish Academy of Sciences
- Bartek Wilczyński
- Faculty of Mathematics, Informatics and Mechanics, University of Warsaw
- DOI
- https://doi.org/10.1038/s41467-021-23922-2
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 17
Abstract
Gliomas are tumors often associated with epigenetics-related gene deregulation. Here the authors reveal an atlas of active enhancers and promoters in benign and malignant gliomas by performing whole-genome mapping of chromatin accessibility, histone modifications, DNA methylation patterns and transcriptome analysis simultaneously in multiple tumor samples.
