Nature Communications (Dec 2019)
Barrier-to-autointegration factor 1 (Banf1) regulates poly [ADP-ribose] polymerase 1 (PARP1) activity following oxidative DNA damage
- Emma Bolderson,
- Joshua T. Burgess,
- Jun Li,
- Neha S. Gandhi,
- Didier Boucher,
- Laura V. Croft,
- Samuel Beard,
- Jennifer J. Plowman,
- Amila Suraweera,
- Mark N. Adams,
- Ali Naqi,
- Shu-Dong Zhang,
- David A. Sinclair,
- Kenneth J. O’Byrne,
- Derek J. Richard
Affiliations
- Emma Bolderson
- Cancer & Ageing Research Program, Institute of Health and Biomedical Innovation at the Translational Research Institute (TRI), Queensland University of Technology (QUT)
- Joshua T. Burgess
- Cancer & Ageing Research Program, Institute of Health and Biomedical Innovation at the Translational Research Institute (TRI), Queensland University of Technology (QUT)
- Jun Li
- Department of Genetics, Paul F. Glenn Center for Biology of Aging Research, Harvard Medical School
- Neha S. Gandhi
- School of Mathematical Sciences, Queensland University of Technology
- Didier Boucher
- Cancer & Ageing Research Program, Institute of Health and Biomedical Innovation at the Translational Research Institute (TRI), Queensland University of Technology (QUT)
- Laura V. Croft
- Cancer & Ageing Research Program, Institute of Health and Biomedical Innovation at the Translational Research Institute (TRI), Queensland University of Technology (QUT)
- Samuel Beard
- Cancer & Ageing Research Program, Institute of Health and Biomedical Innovation at the Translational Research Institute (TRI), Queensland University of Technology (QUT)
- Jennifer J. Plowman
- Cancer & Ageing Research Program, Institute of Health and Biomedical Innovation at the Translational Research Institute (TRI), Queensland University of Technology (QUT)
- Amila Suraweera
- Cancer & Ageing Research Program, Institute of Health and Biomedical Innovation at the Translational Research Institute (TRI), Queensland University of Technology (QUT)
- Mark N. Adams
- Cancer & Ageing Research Program, Institute of Health and Biomedical Innovation at the Translational Research Institute (TRI), Queensland University of Technology (QUT)
- Ali Naqi
- Cancer & Ageing Research Program, Institute of Health and Biomedical Innovation at the Translational Research Institute (TRI), Queensland University of Technology (QUT)
- Shu-Dong Zhang
- Northern Ireland Centre for Stratified Medicine, University of Ulster
- David A. Sinclair
- Department of Genetics, Paul F. Glenn Center for Biology of Aging Research, Harvard Medical School
- Kenneth J. O’Byrne
- Cancer & Ageing Research Program, Institute of Health and Biomedical Innovation at the Translational Research Institute (TRI), Queensland University of Technology (QUT)
- Derek J. Richard
- Cancer & Ageing Research Program, Institute of Health and Biomedical Innovation at the Translational Research Institute (TRI), Queensland University of Technology (QUT)
- DOI
- https://doi.org/10.1038/s41467-019-13167-5
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 12
Abstract
Mutation of the nuclear envelope protein, barrier-to-autointegration factor 1 (Banf1), has previously been associated with the development of ageing associated diseases in a human progeria syndrome. Here, the authors reveal the functional link between Banf1-regulated, PARP1-directed repair of oxidative lesions.
