The Medium-Resolution Spectrometer on the Mid-Infrared Instrument on the JWST obtained spectra of three carbon stars in the Large Magellanic Cloud. Two of the spectra differ significantly from spectra obtained ∼16–19 years earlier with the Infrared Spectrograph on the Spitzer Space Telescope. The one semi-regular variable among the three has changed little. The long-period Mira variable in the sample shows changes consistent with its pulsation cycle. The short-period Mira shows dramatic changes in the strength of its molecular absorption bands, with some bands growing weaker and some stronger. Whether these variations result from its pulsation cycle or its evolution is not clear.