Analysis of cancer genomes reveals basic features of human aging and its role in cancer development

Dmitriy I. Podolskiy; Alexei V. Lobanov; Gregory V. Kryukov; Vadim N. Gladyshev

doi:10.1038/ncomms12157

Nature Communications (Aug 2016)

Analysis of cancer genomes reveals basic features of human aging and its role in cancer development

Dmitriy I. Podolskiy,
Alexei V. Lobanov,
Gregory V. Kryukov,
Vadim N. Gladyshev

Affiliations

Dmitriy I. Podolskiy: Division of Genetics, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School
Alexei V. Lobanov: Division of Genetics, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School
Gregory V. Kryukov: Broad Institute
Vadim N. Gladyshev: Division of Genetics, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School

DOI: https://doi.org/10.1038/ncomms12157
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 12

Abstract

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Somatic mutations are associated with disease, including cancer. Here, the authors analyse cancer genomic data and show that somatic mutations increase with age and that cancer incidence lags 15 years behind this increase, later in life, mutation and cancer incidence are reduced.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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