Effect of vitamin D3 on lung damage induced by cigarette smoke in mice
Zheng Xin,
Qu Nini,
Wang Lina,
Wang Guoli,
Jiao Rui,
Deng Hu,
Li Sijia,
Qin Yibing
Affiliations
Zheng Xin
Respiratory Department, Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, NO.33 Beiling Street, Huanggu District, Shenyang, 110032, Liaoning, P.R.China
Qu Nini
Respiratory Department, Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, NO.33 Beiling Street, Huanggu District, Shenyang, 110032, Liaoning, P.R.China
Wang Lina
Respiratory Department, Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, NO.33 Beiling Street, Huanggu District, Shenyang, 110032, Liaoning, P.R.China
Wang Guoli
Respiratory Department, Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, NO.33 Beiling Street, Huanggu District, Shenyang, 110032, Liaoning, P.R.China
Jiao Rui
Respiratory Department, Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, NO.33 Beiling Street, Huanggu District, Shenyang, 110032, Liaoning, P.R.China
Deng Hu
Respiratory Department, Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, NO.33 Beiling Street, Huanggu District, Shenyang, 110032, Liaoning, P.R.China
Li Sijia
Liaoning University of Traditional Chinese Medicine, Shenyang, 110847, Liaoning, P.R.China
Qin Yibing
Liaoning University of Traditional Chinese Medicine, Shenyang, 110847, Liaoning, P.R.China
Cigarette smoking is known to induce serious lung diseases, but there is not an effective method to solve this problem. The present study investigated vitamin D3 on over-expression of CXCR3 and CXCL10 in mice induced by cigarette smoking. A pulmonary airway model was designed, and morphological assessment of emphysema, IL-4, IFN-γ and CXCL10 concentration in bronchoalveolar lavage fluids, expression of CXCR3 and CXCL10 were detected. Emphysema of the mice only exposed to cigarette smoke was significant, and concentration of IL-4, IFN-γ and CXCL10 was also increased. In addition, CXCR3 and CXCL10 were over-expressed. The degree of emphysema, concentration of IL-4, IFN-γ and CXCL10, and expression of CXCR3 and CXCL10 in mice administrated with low dose vitamin D3 were similar to the normally treated mice. Low dose of vitamin D3 can effectively protect the lung from the damage induced by cigarette smoke.
