Pharmaceutical evaluation and comparison of different brands of metronidazole available in the local market of Peshawar (Pakistan)

Journal of Coastal Life Medicine. 2016;4(8):639-644 DOI 10.12980/jclm.4.2016J6-101

 

Journal Homepage

Journal Title: Journal of Coastal Life Medicine

ISSN: 2309-5288 (Print); 2309-6152 (Online)

Publisher:  Journal of Coastal Life Medicine Editorial Office

Society/Institution:  Journal of Coastal Life Medicine Editorial Office

LCC Subject Category: Medicine: Medicine (General) | Science: Biology (General)

Country of publisher: Hong Kong

Language of fulltext: English

Full-text formats available: PDF

 

AUTHORS

Muhammad Adil (Department of Pharmacy, Sarhad University of Science and Information Technology, Peshawar, Khyber Pakhtunkhwa, Pakistan)
Aasif Awan (Health Biotechnology, Institute of Biotechnology and Genetic Engineering, The University of Agriculture, Peshawar, Pakistan)
Sudhair Abbas (Department of Pharmacy, Sarhad University of Science and Information Technology, Peshawar, Khyber Pakhtunkhwa, Pakistan)
Kamran Chishti (Department of Pharmacy, Sarhad University of Science and Information Technology, Peshawar, Khyber Pakhtunkhwa, Pakistan)
Lateef Ahmad (Department of Pharmacy, University of Sawabi, Khyber Pakhtunkhwa, Pakistan)

EDITORIAL INFORMATION

Peer review

Editorial Board

Instructions for authors

Time From Submission to Publication: 4 weeks

 

Abstract | Full Text

Objective: To assess the pharmaceutical quality of different brands of metronidazole manufactured, available and prescribed by the doctors of Peshawar, Pakistan. Methods: Different film-coated metronidazole products manufactured by multinational and national pharmaceutical industries and prescribed by the doctors were collected from Peshawar, Khyber Pakhtunkhwa, Pakistan. Their hysico-chemical properties were assessed, which included friability, hardness, disintegration, dissolution and weight variation tests according to the the United States Pharmacopoeia (USP) standards. Results: All the brands showed a average weight of 5.74 g for 13 tablets (products A–M). Product J had the highest weight and products D and E failed the hardness, friability and disintegration time according to USP standards. Products M, K and G, L failed disintegration test and dissolution test, respectively. Weight variation of all the products proved statistically that they were in accordance with the standards of USP. Conclusions: The study suggested that products A, F, H and J passed all the tests according to the USP standards while the rest of them did not fulfill the standards specification.