Dual checkpoint targeting of B7-H3 and PD-1 with enoblituzumab and pembrolizumab in advanced solid tumors: interim results from a multicenter phase I/II trial

• Xiaoyu Zhang,
• Anthony M Joshua,
• Sanjeev Kaul,
• Scott Antonia,
• Robert L Ferris,
• Roger B Cohen,
• Ezio Bonvini,
• Jan Baughman,
• Victoria Atkinson,
• Charu Aggarwal,
• Nicholas Vogelzang,
• Osama Rahma,
• Mahesh Seetharam,
• Yanyan Lou,
• Anthony Tolcher,
• Fernanda I Arnaldez,
• Amy Prawira,
• Ralph Hauke,
• Vinod Ganju,
• Andrew Weickhardt,
• Dan P Zandberg,
• Arash Rezazadeh Kalebasty,
• Alex A Adjei,
• Ariel Birnbaum,
• Rosetta Cavallo,
• Linda Peng,
• Paul A Moore,
• Stacie M Goldberg,
• Nehal J Lakhani

Affiliations

Xiaoyu Zhang

Department of Ophthalmology, Eye & ENT Hospital, Fudan University, Shanghai, China

Anthony M Joshua

Cancer Research, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia

Sanjeev Kaul

Hackensack University Medical Center, Hackensack, New Jersey, USA

Scott Antonia

Aff8 grid.468198.a0000 0000 9891 5233H. Lee Moffit Cancer Center and Research Institute USA

Robert L Ferris

UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania, USA

Roger B Cohen

Aff1 grid.25879.310000000419368972University of Pennsylvania School of Medicine Philadelphia PA USA

Ezio Bonvini

Aff3 grid.421076.6MacroGenics, Inc., Rockville Rockville MD United States

Jan Baughman

Aff2 grid.421076.6MacroGenics, Inc. Rockville MD USA

Victoria Atkinson

17 Gallipoli Medical Research Foundation and University of Queensland, Brisbane, Queensland, Australia

Charu Aggarwal

Aff452 grid.25879.310000000419368972University of Pennsylvania Philadelphia PA USA

Nicholas Vogelzang

Aff2 US Oncology Research, Comprehensive Cancer Centers Las Vegas NV USA

Osama Rahma

Center for Cancer Therapeutic Innovation, Gastrointestinal Cancer Center, Dana-Farber Cancer Institute, Boston, Massachusetts, USA

Mahesh Seetharam

3Mayo Clinic, Rochester, MN, USA

Yanyan Lou

Aff1 0000 0004 0443 9942grid.417467.7Department of Hematology and OncologyMayo Clinic 4500 San Pablo Road 32224 Jacksonville FL USA

Anthony Tolcher

6Next Onoclogy, San Antonio, TX, USA

Fernanda I Arnaldez

1 MacroGenics Inc, Rockville, Maryland, USA

Amy Prawira

Department of Medical Oncology, The Kinghorn Cancer Centre, St Vincent’s Hospital, Sidney, New South Wales, Australia

Ralph Hauke

8 Medicine, Nebraska Cancer Specialists, Omaha, Nebraska, USA

Vinod Ganju

Department of Medical Oncology, Monash Medical Centre, East Bentleigh, Melbourne, Australia

Andrew Weickhardt

10Olivia Newton-John Cancer Wellness and Res, Heidelberg, VT, Australia

Dan P Zandberg

UPMC Hillman Cancer Center, Pittsburgh, Pennsylvania, USA

Arash Rezazadeh Kalebasty

Norton Cancer Institute, Louisville, Kentucky, USA

Alex A Adjei

Mayo Clinic, Rochester, Minnesota, USA

Ariel Birnbaum

Rhode Island Hospital, Providence, Rhode Island, USA

Rosetta Cavallo

MacroGenics, Inc, Rockville, Maryland, USA

Linda Peng

MacroGenics, Inc, Rockville, Maryland, USA

Paul A Moore

MacroGenics, Inc, Rockville, Maryland, USA

Stacie M Goldberg

MacroGenics, Inc, Rockville, Maryland, USA

Nehal J Lakhani

START Midwest, Grand Rapids, Michigan, USA