Structural determinants of Rab11 activation by the guanine nucleotide exchange factor SH3BP5

Meredith L. Jenkins; Jean Piero Margaria; Jordan T. B. Stariha; Reece M. Hoffmann; Jacob A. McPhail; David J. Hamelin; Martin J. Boulanger; Emilio Hirsch; John E. Burke

doi:10.1038/s41467-018-06196-z

Nature Communications (Sep 2018)

Structural determinants of Rab11 activation by the guanine nucleotide exchange factor SH3BP5

Meredith L. Jenkins,
Jean Piero Margaria,
Jordan T. B. Stariha,
Reece M. Hoffmann,
Jacob A. McPhail,
David J. Hamelin,
Martin J. Boulanger,
Emilio Hirsch,
John E. Burke

Affiliations

Meredith L. Jenkins: Department of Biochemistry and Microbiology, University of Victoria
Jean Piero Margaria: Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Turin
Jordan T. B. Stariha: Department of Biochemistry and Microbiology, University of Victoria
Reece M. Hoffmann: Department of Biochemistry and Microbiology, University of Victoria
Jacob A. McPhail: Department of Biochemistry and Microbiology, University of Victoria
David J. Hamelin: Department of Biochemistry and Microbiology, University of Victoria
Martin J. Boulanger: Department of Biochemistry and Microbiology, University of Victoria
Emilio Hirsch: Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Turin
John E. Burke: Department of Biochemistry and Microbiology, University of Victoria

DOI: https://doi.org/10.1038/s41467-018-06196-z
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 13

Abstract

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Rab11 GTPases are involved in various cellular processes but their activation by guanine nucleotide exchange factors (GEFs) is not fully understood. Here, the authors present a structural and biochemical analysis of Rab11 bound to the GEF SH3BP5, providing insights how Rab-GEF specificity is achieved.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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