Nature Communications (Feb 2021)
L1 retrotransposons exploit RNA m6A modification as an evolutionary driving force
- Sung-Yeon Hwang,
- Hyunchul Jung,
- Seyoung Mun,
- Sungwon Lee,
- Kiwon Park,
- S. Chan Baek,
- Hyungseok C. Moon,
- Hyewon Kim,
- Baekgyu Kim,
- Yongkuk Choi,
- Young-Hyun Go,
- Wanxiangfu Tang,
- Jongsu Choi,
- Jung Kyoon Choi,
- Hyuk-Jin Cha,
- Hye Yoon Park,
- Ping Liang,
- V. Narry Kim,
- Kyudong Han,
- Kwangseog Ahn
Affiliations
- Sung-Yeon Hwang
- Center for RNA Research, Institute for Basic Science
- Hyunchul Jung
- Department of Bio and Brain Engineering, KAIST
- Seyoung Mun
- Department of Nanobiomedical Science, Dankook University
- Sungwon Lee
- Center for RNA Research, Institute for Basic Science
- Kiwon Park
- Center for RNA Research, Institute for Basic Science
- S. Chan Baek
- Center for RNA Research, Institute for Basic Science
- Hyungseok C. Moon
- Department of Physics and Astronomy, Seoul National University
- Hyewon Kim
- Center for RNA Research, Institute for Basic Science
- Baekgyu Kim
- Center for RNA Research, Institute for Basic Science
- Yongkuk Choi
- Center for RNA Research, Institute for Basic Science
- Young-Hyun Go
- Department of Pharmacy, Seoul National University
- Wanxiangfu Tang
- Department of Biological Sciences, Brock University
- Jongsu Choi
- Dr. von Hauner Children’s Hospital, Ludwig-Maximilians-University of Munich
- Jung Kyoon Choi
- Department of Bio and Brain Engineering, KAIST
- Hyuk-Jin Cha
- Department of Pharmacy, Seoul National University
- Hye Yoon Park
- Department of Physics and Astronomy, Seoul National University
- Ping Liang
- Department of Biological Sciences, Brock University
- V. Narry Kim
- Center for RNA Research, Institute for Basic Science
- Kyudong Han
- DKU-Theragen institute for NGS analysis (DTiNa)
- Kwangseog Ahn
- Center for RNA Research, Institute for Basic Science
- DOI
- https://doi.org/10.1038/s41467-021-21197-1
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 14
Abstract
L1 is a group of active retrotransposons in humans. Here the authors show that m6A modifications on L1 RNA increase translation efficiency and retrotransposition in human cells. M6A motifs are more enriched in evolutionary young L1s.
