How nanoscale protein interactions determine the mesoscale dynamic organisation of bacterial outer membrane proteins

Matthieu Chavent; Anna L. Duncan; Patrice Rassam; Oliver Birkholz; Jean Hélie; Tyler Reddy; Dmitry Beliaev; Ben Hambly; Jacob Piehler; Colin Kleanthous; Mark S. P. Sansom

doi:10.1038/s41467-018-05255-9

Nature Communications (Jul 2018)

How nanoscale protein interactions determine the mesoscale dynamic organisation of bacterial outer membrane proteins

Matthieu Chavent,
Anna L. Duncan,
Patrice Rassam,
Oliver Birkholz,
Jean Hélie,
Tyler Reddy,
Dmitry Beliaev,
Ben Hambly,
Jacob Piehler,
Colin Kleanthous,
Mark S. P. Sansom

Affiliations

Matthieu Chavent: Department of Biochemistry, University of Oxford
Anna L. Duncan: Department of Biochemistry, University of Oxford
Patrice Rassam: Department of Biochemistry, University of Oxford
Oliver Birkholz: Department of Biology, University of Osnabrück
Jean Hélie: Department of Biochemistry, University of Oxford
Tyler Reddy: Department of Biochemistry, University of Oxford
Dmitry Beliaev: Mathematical Institute, University of Oxford
Ben Hambly: Mathematical Institute, University of Oxford
Jacob Piehler: Department of Biology, University of Osnabrück
Colin Kleanthous: Department of Biochemistry, University of Oxford
Mark S. P. Sansom: Department of Biochemistry, University of Oxford

DOI: https://doi.org/10.1038/s41467-018-05255-9
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 12

Abstract

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In Escherichia coli, outer membrane protein (OMP) cluster and form islands, but the origin and behaviour of those clusters remains poorly understood. Here authors use coarse grained molecular dynamics simulation and show that their mesoscale simulations recapitulate the restricted diffusion characteristics of OMPs.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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