Arcuate fasciculus architecture is associated with individual differences in pre-attentive detection of unpredicted music changes
Lucía Vaquero,
Neus Ramos-Escobar,
David Cucurell,
Clément François,
Vesa Putkinen,
Emma Segura,
Minna Huotilainen,
Virginia Penhune,
Antoni Rodríguez-Fornells
Affiliations
Lucía Vaquero
Laboratory of Cognitive and Computational Neuroscience, Complutense University of Madrid and Polytechnic University of Madrid, Campus Científico y Tecnológico de la UPM, Pozuelo de Alarcón, 28223 Madrid, Spain; Corresponding author.
Neus Ramos-Escobar
Department of Cognition, Development and Education Psychology, and Institute of Neurosciences, University of Barcelona, Barcelona, Spain; Cognition and Brain Plasticity Unit, Bellvitge Biomedical Research Institute (IDIBELL). L'Hospitalet de Llobregat, Barcelona, Spain
David Cucurell
Department of Cognition, Development and Education Psychology, and Institute of Neurosciences, University of Barcelona, Barcelona, Spain; Cognition and Brain Plasticity Unit, Bellvitge Biomedical Research Institute (IDIBELL). L'Hospitalet de Llobregat, Barcelona, Spain
Clément François
Cognition and Brain Plasticity Unit, Bellvitge Biomedical Research Institute (IDIBELL). L'Hospitalet de Llobregat, Barcelona, Spain; Aix Marseille Univ, CNRS, LPL, Aix-en-Provence, France
Vesa Putkinen
Turku PET Centre, University of Turku, Turku, Finland
Emma Segura
Department of Cognition, Development and Education Psychology, and Institute of Neurosciences, University of Barcelona, Barcelona, Spain; Cognition and Brain Plasticity Unit, Bellvitge Biomedical Research Institute (IDIBELL). L'Hospitalet de Llobregat, Barcelona, Spain
Minna Huotilainen
Cicero Learning and Cognitive Brain Research Unit, University of Helsinki, Helsinki, Finland
Virginia Penhune
Penhune Laboratory for Motor Learning and Neural Plasticity, Concordia University, Montreal, QC, Canada; International Laboratory for Brain, Music and Sound Research (BRAMS). Montreal, QC, Canada; Center for Research on Brain, Language and Music (CRBLM), McGill University. Montreal, QC, Canada
Antoni Rodríguez-Fornells
Department of Cognition, Development and Education Psychology, and Institute of Neurosciences, University of Barcelona, Barcelona, Spain; Cognition and Brain Plasticity Unit, Bellvitge Biomedical Research Institute (IDIBELL). L'Hospitalet de Llobregat, Barcelona, Spain; Institució Catalana de recerca i Estudis Avançats (ICREA), Barcelona, Spain
The mismatch negativity (MMN) is an event related brain potential (ERP) elicited by unpredicted sounds presented in a sequence of repeated auditory stimuli. The neural sources of the MMN have been previously attributed to a fronto-temporo-parietal network which crucially overlaps with the so-called auditory dorsal stream, involving inferior and middle frontal, inferior parietal, and superior and middle temporal regions. These cortical areas are structurally connected by the arcuate fasciculus (AF), a three-branch pathway supporting the feedback-feedforward loop involved in auditory-motor integration, auditory working memory, storage of acoustic templates, as well as comparison and update of those templates. Here, we characterized the individual differences in the white-matter macrostructural properties of the AF and explored their link to the electrophysiological marker of passive change detection gathered in a melodic multifeature MMN-EEG paradigm in 26 healthy young adults without musical training. Our results show that left fronto-temporal white-matter connectivity plays an important role in the pre-attentive detection of rhythm modulations within a melody. Previous studies have shown that this AF segment is also critical for language processing and learning. This strong coupling between structure and function in auditory change detection might be related to life-time linguistic (and possibly musical) exposure and experiences, as well as to timing processing specialization of the left auditory cortex. To the best of our knowledge, this is the first time in which the relationship between neurophysiological (EEG) and brain white-matter connectivity indexes using DTI-tractography are studied together. Thus, the present results, although still exploratory, add to the existing evidence on the importance of studying the constraints imposed on cognitive functions by the underlying structural connectivity.
