Hyperstretching DNA

Koen Schakenraad; Andreas S. Biebricher; Maarten Sebregts; Brian ten Bensel; Erwin J. G. Peterman; Gijs J. L. Wuite; Iddo Heller; Cornelis Storm; Paul van der Schoot

doi:10.1038/s41467-017-02396-1

Nature Communications (Dec 2017)

Hyperstretching DNA

Koen Schakenraad,
Andreas S. Biebricher,
Maarten Sebregts,
Brian ten Bensel,
Erwin J. G. Peterman,
Gijs J. L. Wuite,
Iddo Heller,
Cornelis Storm,
Paul van der Schoot

Affiliations

Koen Schakenraad: Department of Applied Physics, Eindhoven University of Technology
Andreas S. Biebricher: Department of Physics and Astronomy, LaserLaB Amsterdam, Vrije Universiteit Amsterdam
Maarten Sebregts: Department of Applied Physics, Eindhoven University of Technology
Brian ten Bensel: Department of Physics and Astronomy, LaserLaB Amsterdam, Vrije Universiteit Amsterdam
Erwin J. G. Peterman: Department of Physics and Astronomy, LaserLaB Amsterdam, Vrije Universiteit Amsterdam
Gijs J. L. Wuite: Department of Physics and Astronomy, LaserLaB Amsterdam, Vrije Universiteit Amsterdam
Iddo Heller: Department of Physics and Astronomy, LaserLaB Amsterdam, Vrije Universiteit Amsterdam
Cornelis Storm: Department of Applied Physics, Eindhoven University of Technology
Paul van der Schoot: Department of Applied Physics, Eindhoven University of Technology

DOI: https://doi.org/10.1038/s41467-017-02396-1
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 7

Abstract

Read online

The mechanics and structural transitions of DNA are important to many essential processes inside living cells. Here the authors combine theory and single-molecule experiments to show that intercalator binding stabilises a new structural state of DNA: hyperstretched DNA.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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