Is pharmacokinetic-guided dosing of desmopressin and von Willebrand factor-containing concentrates in individuals with von Willebrand disease or low von Willebrand factor reliable and feasible? A protocol for a multicentre, non-randomised, open label cohort trial, the OPTI-CLOT: to WiN study

• ,
• Marjon H Cnossen,
• Frank W G Leebeek,
• Ron A A Mathôt,
• M Coppens,
• MJHA Kruip,
• S Polinder,
• K Fischer,
• R Liesner,
• K Fijnvandraat,
• Laura H Bukkems,
• PW Collins,
• P Chowdary,
• K Meijer,
• A Janssen,
• MH Cnossen,
• Jessica M Heijdra,
• Wala Al Arashi,
• Nico C B de Jager,
• Michael E Cloesmeijer,
• Christian M Zwaan,
• FWG Leebeek,
• RAA Mathôt,
• RYJ Tamminga,
• BAP Laros-van Gorkom,
• P Brons,
• SEM Schols,
• FJM van der Meer,
• HCJ Eikenboom,
• REG Schutgens,
• F Heubel-Moenen,
• L Nieuwenhuizen,
• P Ypma,
• MHE Driessens,
• CM Zwaan,
• I van Vliet,
• D Keeling,
• J Lock,
• HCAM Hazendonk,
• I van Moort,
• T Preijers,
• JM Heijdra,
• NCB de Jager,
• MCHJ Goedhart,
• LH Bukkems,
• W Al Arashi,
• ME Cloesmeijer

Affiliations

Marjon H Cnossen

Department of Pediatric Hematology, Erasmus MC - Sophia Children’s Hospital, University Medical Center Rotterdam, Rotterdam, the Netherlands

Frank W G Leebeek

Department of Hematology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands

Ron A A Mathôt

Hospital Pharmacy - Clinical Pharmacology, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands

M Coppens

MJHA Kruip

S Polinder

K Fischer

R Liesner

K Fijnvandraat

Laura H Bukkems

Hospital Pharmacy - Clinical Pharmacology, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands

PW Collins

P Chowdary

K Meijer

A Janssen

MH Cnossen

Jessica M Heijdra

Department of Pediatric Hematology, Erasmus MC - Sophia Children’s Hospital, University Medical Center Rotterdam, Rotterdam, the Netherlands

Wala Al Arashi

Department of Pediatric Hematology, Erasmus MC - Sophia Children’s Hospital, University Medical Center Rotterdam, Rotterdam, the Netherlands

Nico C B de Jager

Hospital Pharmacy - Clinical Pharmacology, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands

Michael E Cloesmeijer

Hospital Pharmacy - Clinical Pharmacology, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands

Christian M Zwaan

Department of Pediatric Oncology, Erasmus MC - Sophia Children’s Hospital, University Medical Center Rotterdam, Rotterdam, the Netherlands

FWG Leebeek

RAA Mathôt

RYJ Tamminga

BAP Laros-van Gorkom

P Brons

SEM Schols

FJM van der Meer

HCJ Eikenboom

REG Schutgens

F Heubel-Moenen

L Nieuwenhuizen

P Ypma

MHE Driessens

CM Zwaan

I van Vliet

D Keeling

J Lock

HCAM Hazendonk

I van Moort

T Preijers

JM Heijdra

NCB de Jager

MCHJ Goedhart

LH Bukkems

W Al Arashi

ME Cloesmeijer