Nature Communications (Sep 2022)
Adipocyte-derived lactate is a signalling metabolite that potentiates adipose macrophage inflammation via targeting PHD2
- Tianshi Feng,
- Xuemei Zhao,
- Ping Gu,
- Wah Yang,
- Cunchuan Wang,
- Qingyu Guo,
- Qiaoyun Long,
- Qing Liu,
- Ying Cheng,
- Jin Li,
- Cynthia Kwan Yui Cheung,
- Donghai Wu,
- Xinyu Kong,
- Yong Xu,
- Dewei Ye,
- Shuang Hua,
- Kerry Loomes,
- Aimin Xu,
- Xiaoyan Hui
Affiliations
- Tianshi Feng
- State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong
- Xuemei Zhao
- School of Biomedical Sciences, The Chinese University of Hong Kong
- Ping Gu
- Department of Endocrinology, Jinling Hospital, School of Medicine, Nanjing University
- Wah Yang
- State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong
- Cunchuan Wang
- The First Affiliated Hospital of Jinan University
- Qingyu Guo
- Department of Endocrinology, Jinling Hospital, School of Medicine, Nanjing University
- Qiaoyun Long
- School of Biomedical Sciences, The Chinese University of Hong Kong
- Qing Liu
- State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong
- Ying Cheng
- State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong
- Jin Li
- State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong
- Cynthia Kwan Yui Cheung
- State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong
- Donghai Wu
- Key Laboratory of Regenerative Biology, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences
- Xinyu Kong
- Key Laboratory of Regenerative Biology, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences
- Yong Xu
- Key Laboratory of Regenerative Biology, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences
- Dewei Ye
- Guangdong Pharmaceutical University
- Shuang Hua
- Guangdong Pharmaceutical University
- Kerry Loomes
- School of Biological Sciences and Maurice Wilkins Centre, University of Auckland
- Aimin Xu
- State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong
- Xiaoyan Hui
- State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong
- DOI
- https://doi.org/10.1038/s41467-022-32871-3
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 14
Abstract
Adipocyte tissue macrophages (ATM) are recruited and activated in obesity. The authors show that adipocytes release lactate as a signal of inflammation and that this metabolite can enhance obesity associated inflammation through stimulation of ATM by direct binding with PHD2.
