AN APPLICATION OF DERIVATIZATION BY THE PEROXIC ACID OXIDATION FOR THE DETERMINATION OF FENTIASINE DERIVATIVES BY INDIRECT SPECTROPHYTOMETRY METHOD (A REVIEW)

Abstract

The present article reviews the current state of the UV-spectroscopy method in the pharmaceutical analysis of phenothiazine derivatives. There are three main areas of applied research using UV VIS spectrophotometry in pharmaceutical analysis: quantitative determination of the concentration of organic substances by their own light absorption; resolving the issues of quality control and standardization of medicinal products using UV VIS spectrophotometry; elaboration and improvement of techniques for processing spectral curves, obtaining from them more complete information about the properties of substances. The peculiarities of determination of pharmaceutical substances in various drugs and the problems associated with the use of the chemical reactions prior to UV VIS spectrophotometric measurements are considered. This review article presents the fundamentals for the beginner and, for the expert, discusses quantitative analysis problems. The review of the UV VIS spectrophotometric methods for determination of the main type of pharmaseuticals, such as phenothiazine derivatives is given. The main attention is focused on the achievements of the last decade. The example of piperidine and piperazine derivatives of phenothiazine shows the advantages of using Oxone and diperoxydicarboxylic acids as derivatization reagents for the production of sulfoxides of the corresponding phenothiazines for selective and highly sensitive quantitative determination of them in some pharmaseuticals by UV VIS spectrophotometry.

Keywords

• дериватизація
• оксон
• дипероксидикарбонові кислоти
• спектрофотометрія
• похідні фентіазину