iMeta (Feb 2025)
Gut–X axis
- Xu Lin,
- Zuxiang Yu,
- Yang Liu,
- Changzhou Li,
- Hui Hu,
- Jia‐Chun Hu,
- Mian Liu,
- Qin Yang,
- Peng Gu,
- Jiaxin Li,
- Kutty Selva Nandakumar,
- Gaofei Hu,
- Qi Zhang,
- Xinyu Chen,
- Huihui Ma,
- Wenye Huang,
- Gaofeng Wang,
- Yan Wang,
- Liping Huang,
- Wenjuan Wu,
- Ning‐Ning Liu,
- Chenhong Zhang,
- Xingyin Liu,
- Leming Zheng,
- Peng Chen
Affiliations
- Xu Lin
- Department of Endocrinology and Metabolism Shunde Hospital of Southern Medical University (The First People's Hospital of Shunde) Foshan City 528308 China
- Zuxiang Yu
- State Key Laboratory of Vascular Homeostasis and Remodeling, NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Beijing Key Laboratory of Cardiovascular Receptors Research, Health Science Center, The Institute of Cardiovascular Sciences and Institute of Systems Biomedicine Peking University Beijing 100191 China
- Yang Liu
- State Key Laboratory of Reproductive Medicine and Offsprings Health, Center for Global Health Nanjing Medical University Nanjing 211166 China
- Changzhou Li
- Department of Plastic and Aesthetic Surgery, Nanfang Hospital Southern Medical University Guangzhou 510515 China
- Hui Hu
- Department of Laboratory Medicine, Shanghai East Hospital Tongji University School of Medicine Shanghai 200123 China
- Jia‐Chun Hu
- State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia Medica, Chinese Academy of Medical Sciences/Peking Union Medical College Beijing 100050 China
- Mian Liu
- Department of Obstetrics and Gynecology, Nanfang Hospital Southern Medical University Guangzhou 510515 China
- Qin Yang
- Department of Pathophysiology, Guangdong Provincial Key Laboratory of Proteomics, School of Basic Medical Sciences Southern Medical University Guangzhou 510515 China
- Peng Gu
- Department of Pathophysiology, Guangdong Provincial Key Laboratory of Proteomics, School of Basic Medical Sciences Southern Medical University Guangzhou 510515 China
- Jiaxin Li
- Department of Pathophysiology, Guangdong Provincial Key Laboratory of Proteomics, School of Basic Medical Sciences Southern Medical University Guangzhou 510515 China
- Kutty Selva Nandakumar
- Department of Medical Biochemistry and Biophysics Karolinska Institute Stockholm 17177 Sweden
- Gaofei Hu
- State Key Laboratory of Vascular Homeostasis and Remodeling, NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Beijing Key Laboratory of Cardiovascular Receptors Research, Health Science Center, The Institute of Cardiovascular Sciences and Institute of Systems Biomedicine Peking University Beijing 100191 China
- Qi Zhang
- State Key Laboratory of Vascular Homeostasis and Remodeling, NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Beijing Key Laboratory of Cardiovascular Receptors Research, Health Science Center, The Institute of Cardiovascular Sciences and Institute of Systems Biomedicine Peking University Beijing 100191 China
- Xinyu Chen
- State Key Laboratory of Reproductive Medicine and Offsprings Health, Center for Global Health Nanjing Medical University Nanjing 211166 China
- Huihui Ma
- State Key Laboratory of Reproductive Medicine and Offsprings Health, Center for Global Health Nanjing Medical University Nanjing 211166 China
- Wenye Huang
- State Key Laboratory of Reproductive Medicine and Offsprings Health, Center for Global Health Nanjing Medical University Nanjing 211166 China
- Gaofeng Wang
- Department of Plastic and Aesthetic Surgery, Nanfang Hospital Southern Medical University Guangzhou 510515 China
- Yan Wang
- State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia Medica, Chinese Academy of Medical Sciences/Peking Union Medical College Beijing 100050 China
- Liping Huang
- Department of Obstetrics and Gynecology, Nanfang Hospital Southern Medical University Guangzhou 510515 China
- Wenjuan Wu
- Department of Laboratory Medicine, Shanghai East Hospital Tongji University School of Medicine Shanghai 200123 China
- Ning‐Ning Liu
- State Key Laboratory of Systems Medicine for Cancer, Center for Single‐Cell Omics, School of Public Health Shanghai Jiao Tong University School of Medicine Shanghai 200025 China
- Chenhong Zhang
- State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology Shanghai Jiao Tong University Shanghai 200240 China
- Xingyin Liu
- State Key Laboratory of Reproductive Medicine and Offsprings Health, Center for Global Health Nanjing Medical University Nanjing 211166 China
- Leming Zheng
- State Key Laboratory of Vascular Homeostasis and Remodeling, NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Beijing Key Laboratory of Cardiovascular Receptors Research, Health Science Center, The Institute of Cardiovascular Sciences and Institute of Systems Biomedicine Peking University Beijing 100191 China
- Peng Chen
- Department of Pathophysiology, Guangdong Provincial Key Laboratory of Proteomics, School of Basic Medical Sciences Southern Medical University Guangzhou 510515 China
- DOI
- https://doi.org/10.1002/imt2.270
- Journal volume & issue
-
Vol. 4,
no. 1
pp. n/a – n/a
Abstract
Abstract Recent advances in understanding the modulatory functions of gut and gut microbiota on human diseases facilitated our focused attention on the contribution of the gut to the pathophysiological alterations of many extraintestinal organs, including the liver, heart, brain, lungs, kidneys, bone, skin, reproductive, and endocrine systems. In this review, we applied the “gut–X axis” concept to describe the linkages between the gut and other organs and discussed the latest findings related to the “gut–X axis,” including the underlying modulatory mechanisms and potential clinical intervention strategies.
Keywords
