Journal of Multidisciplinary Healthcare (Mar 2024)
Effect of Helicobacter Pylori Infection on Glucose Metabolism, Lipid Metabolism and Inflammatory Cytokines in Nonalcoholic Fatty Liver Disease Patients
Abstract
Qing-Yu Xiao,1 Ren-Ling Wang,2 Hai-Jun Wu,1 Wen-Bin Kuang,3 Wei-Wei Meng,4 Zhen Cheng5 1Department of Blood Transfusion, Shenzhen Baoan Shiyan People’s Hospital, Shenzhen, 518108, China; 2Department of Oncology, Kaiping Central Hospital, Jiangmen City, Guangdong Province, 529399, People’s Republic of China; 3Department of Laboratory, Longhua District Central Hospital, Shenzhen, 518110, People’s Republic of China; 4Department of Laboratory, Shenzhen Baoan Shiyan People’s Hospital, Shenzhen, 518108, China; 5Guantian Community Healthcare Center, Shenzhen Baoan Shiyan People’s Hospital, Shenzhen, Guangdong province, 518100, People’s Republic of ChinaCorrespondence: Zhen Cheng, Guantian Community Healthcare Center, Shenzhen Baoan Shiyan People’s Hospital, About 50 Meters South of hkc Huike Industrial Park, Dezheng Road, Baoan District, Shenzhen, Guangdong province, 518100, People’s Republic of China, Tel +86 13632854050, Email [email protected]: To probe into the influence of Helicobacter pylori (Hp) infection on glucose metabolism, lipid metabolism, and inflammatory cytokines in patients with nonalcoholic fatty liver disease (MASLD).Methods: A total of 140 MASLD patients admitted to our Hospital between June 2020 and May 2021 were selected as the research objects. Based on the presence or absence of Hp infection, they were divided into the study group (73 cases with infection) and control group (67 cases without infection). Glucose metabolism indicators [fasting blood glucose (FBG), 2-hour postprandial glucose (2hPG), fasting insulin (FINS), glycated hemoglobin (HbAlc)], lipid metabolism indicators [total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C)], and inflammatory indicators [interleukin-37 (IL-37), interleukin-18 (IL-18)] were measured and compared between the two groups.Results: In terms of glucose metabolism indicators, the study group exhibited higher levels of FBG (5.84± 0.49 vs 5.40± 0.51, t=2.535, P=0.012), 2hPG (7.26± 1.30 vs 6.50± 1.53, t=3.321, P< 0.001), and FINS (11.13± 4.13 vs 9.12± 3.72, t=3.224, P< 0.001), and Insulin resistance index (HOMA-IR) (2.97± 0.35 VS 2.13± 0.54, t=3.761, P< 0.001) and a lower level of HbAlc (5.25± 0.56 vs 6.12± 0.57, t=5.473, P< 0.001) compared to the control group. Regarding lipid metabolism indicators, the study group exhibited higher levels of TC (5.64± 1.49 vs 5.01± 1.32, t=3.332, P< 0.001), TG (1.89± 0.34 vs 1.32± 0.43, t=3.411, P< 0.001), and LDL-C (3.31± 0.43 vs 2.12± 0.29, t=4.142, P< 0.001), and a lower level of HDL-C (1.45± 0.21 vs 1.78± 0.42, t=4.347, P< 0.001) compared to the control group. As for the inflammatory indicators, the study group exhibited higher levels of IL-37 (45.56± 6.02 vs 34.02± 3.28, t=9.332, P< 0.001) and IL-18 (73.57± 5.82 vs 60.34± 4.84, t=10.141, P< 0.001) compared to the control group.Conclusion: It is crucial to place appropriate emphasis on the impact of Hp infection on the glucose metabolism, lipid metabolism, and inflammatory response in MASLD patients, warranting careful consideration during the treatment of these patients.Keywords: Helicobacter pylori, infection, nonalcoholic fatty liver disease, glucose metabolism, lipid metabolism, inflammatory indicators
