Nature Communications (Jan 2021)
High-fat diet-induced upregulation of exosomal phosphatidylcholine contributes to insulin resistance
- Anil Kumar,
- Kumaran Sundaram,
- Jingyao Mu,
- Gerald W. Dryden,
- Mukesh K. Sriwastva,
- Chao Lei,
- Lifeng Zhang,
- Xiaolan Qiu,
- Fangyi Xu,
- Jun Yan,
- Xiang Zhang,
- Juw Won Park,
- Michael L. Merchant,
- Henry C. L. Bohler,
- Baomei Wang,
- Shuangqin Zhang,
- Chao Qin,
- Ziying Xu,
- Xianlin Han,
- Craig J. McClain,
- Yun Teng,
- Huang-Ge Zhang
Affiliations
- Anil Kumar
- James Graham Brown Cancer Center, Department of Microbiology & Immunology, University of Louisville
- Kumaran Sundaram
- James Graham Brown Cancer Center, Department of Microbiology & Immunology, University of Louisville
- Jingyao Mu
- James Graham Brown Cancer Center, Department of Microbiology & Immunology, University of Louisville
- Gerald W. Dryden
- James Graham Brown Cancer Center, Department of Microbiology & Immunology, University of Louisville
- Mukesh K. Sriwastva
- James Graham Brown Cancer Center, Department of Microbiology & Immunology, University of Louisville
- Chao Lei
- James Graham Brown Cancer Center, Department of Microbiology & Immunology, University of Louisville
- Lifeng Zhang
- James Graham Brown Cancer Center, Department of Microbiology & Immunology, University of Louisville
- Xiaolan Qiu
- James Graham Brown Cancer Center, Department of Microbiology & Immunology, University of Louisville
- Fangyi Xu
- James Graham Brown Cancer Center, Department of Microbiology & Immunology, University of Louisville
- Jun Yan
- James Graham Brown Cancer Center, Department of Microbiology & Immunology, University of Louisville
- Xiang Zhang
- Department of Pharmacology and Toxicology, University of Louisville
- Juw Won Park
- Department of Computer Engineering and Computer Science, University of Louisville
- Michael L. Merchant
- Kidney Disease Program and Clinical Proteomics Center, University of Louisville
- Henry C. L. Bohler
- Department of Reproductive Endocrinology and Infertility, University of Louisville
- Baomei Wang
- Department of Dermatology, University of Pennsylvania
- Shuangqin Zhang
- Peeples Cancer Institute
- Chao Qin
- Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio
- Ziying Xu
- Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio
- Xianlin Han
- Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio
- Craig J. McClain
- Department of Medicine, University of Louisville
- Yun Teng
- James Graham Brown Cancer Center, Department of Microbiology & Immunology, University of Louisville
- Huang-Ge Zhang
- James Graham Brown Cancer Center, Department of Microbiology & Immunology, University of Louisville
- DOI
- https://doi.org/10.1038/s41467-020-20500-w
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 21
Abstract
High-fat diet plays a role in development of insulin resistance. Here, the authors report a mechanism that underlies the development of diet induced insulin resistance through the activation of an aryl hydrocarbon receptor mediated signalling pathway in the liver by faecal exosomes derived from intestinal cells.
