Loss of Zfp335 triggers cGAS/STING-dependent apoptosis of post-β selection thymocytes

Jeremy J. Ratiu; William E. Barclay; Elliot Lin; Qun Wang; Sebastian Wellford; Naren Mehta; Melissa J. Harnois; Devon DiPalma; Sumedha Roy; Alejandra V. Contreras; Mari L. Shinohara; David Wiest; Yuan Zhuang

doi:10.1038/s41467-022-33610-4

Nature Communications (Oct 2022)

Loss of Zfp335 triggers cGAS/STING-dependent apoptosis of post-β selection thymocytes

Jeremy J. Ratiu,
William E. Barclay,
Elliot Lin,
Qun Wang,
Sebastian Wellford,
Naren Mehta,
Melissa J. Harnois,
Devon DiPalma,
Sumedha Roy,
Alejandra V. Contreras,
Mari L. Shinohara,
David Wiest,
Yuan Zhuang

Affiliations

Jeremy J. Ratiu: Duke University, Department of Immunology
William E. Barclay: Duke University, Department of Immunology
Elliot Lin: Duke University, Department of Immunology
Qun Wang: Duke University, Department of Immunology
Sebastian Wellford: Duke University, Department of Immunology
Naren Mehta: Duke University, Department of Immunology
Melissa J. Harnois: Duke University, Department of Immunology
Devon DiPalma: Duke University, Department of Immunology
Sumedha Roy: Duke University, Department of Immunology
Alejandra V. Contreras: Fox Chase Cancer Center, Blood Cell Development and Function Program
Mari L. Shinohara: Duke University, Department of Immunology
David Wiest: Fox Chase Cancer Center, Blood Cell Development and Function Program
Yuan Zhuang: Duke University, Department of Immunology

DOI: https://doi.org/10.1038/s41467-022-33610-4
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 18

Abstract

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T cell development involves extensive proliferation of developing thymocytes. Here, the authors demonstrate that the transcription factor Zfp335 regulates the survival post-β-selection thymocytes via the cGAS/STING pathway.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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