小胶质细胞对卒中后中枢性疼痛调节机制的研究进展 Research Progress of Microglia on Mediating Central Post-Stroke Pain

Abstract

卒中后中枢性疼痛（central post-stroke pain，CPSP）是常见的卒中并发的神经病理性疼痛综合征，严重影响卒中患者的后期康复和生活质量。近年来，CPSP的病理机制研究逐渐受到重视，而小胶质细胞作为颅内常驻的巨噬细胞，被认为在CPSP发生发展中起重要调节作用。本篇综述从生物活性因子、细胞受体和信号通路等角度总结了近年来小胶质细胞调节CPSP的研究进展，描述了多个化合物对CPSP的临床前治疗作用，以期促进CPSP靶向治疗策略的发展。 Abstract: Central post-stroke pain (CPSP) is a common neuropathic pain syndrome associated with stroke, which severely affects the outcome and life quality of stroke patients. In recent years, more and more attention has been paid to the study of the pathological mechanism of CPSP. Microglia, the resident macrophage within the central nervous system, is considered to play a critical role in the development of CPSP. The present review summarized recent research progress of microglia in mediating CPSP from the perspective of bioactive factors, cellular receptors, and signaling pathways, and described the preclinical therapeutic effects of several compounds on CPSP, hoping to promote the development of targeted therapeutic strategies for CPSP.

Keywords

• 卒中后中枢性疼痛
• 小胶质细胞
• 神经炎症
• central post-stroke pain
• microglia
• neuroinflammation