Nature Communications (Jun 2019)
An integrative cross-omics analysis of DNA methylation sites of glucose and insulin homeostasis
- Jun Liu,
- Elena Carnero-Montoro,
- Jenny van Dongen,
- Samantha Lent,
- Ivana Nedeljkovic,
- Symen Ligthart,
- Pei-Chien Tsai,
- Tiphaine C. Martin,
- Pooja R. Mandaviya,
- Rick Jansen,
- Marjolein J. Peters,
- Liesbeth Duijts,
- Vincent W. V. Jaddoe,
- Henning Tiemeier,
- Janine F. Felix,
- Gonneke Willemsen,
- Eco J. C. de Geus,
- Audrey Y. Chu,
- Daniel Levy,
- Shih-Jen Hwang,
- Jan Bressler,
- Rahul Gondalia,
- Elias L. Salfati,
- Christian Herder,
- Bertha A. Hidalgo,
- Toshiko Tanaka,
- Ann Zenobia Moore,
- Rozenn N. Lemaitre,
- Min A Jhun,
- Jennifer A. Smith,
- Nona Sotoodehnia,
- Stefania Bandinelli,
- Luigi Ferrucci,
- Donna K. Arnett,
- Harald Grallert,
- Themistocles L. Assimes,
- Lifang Hou,
- Andrea Baccarelli,
- Eric A. Whitsel,
- Ko Willems van Dijk,
- Najaf Amin,
- André G. Uitterlinden,
- Eric J. G. Sijbrands,
- Oscar H. Franco,
- Abbas Dehghan,
- Tim D. Spector,
- Josée Dupuis,
- Marie-France Hivert,
- Jerome I. Rotter,
- James B. Meigs,
- James S. Pankow,
- Joyce B. J. van Meurs,
- Aaron Isaacs,
- Dorret I. Boomsma,
- Jordana T. Bell,
- Ayşe Demirkan,
- Cornelia M. van Duijn
Affiliations
- Jun Liu
- Department of Epidemiology, Erasmus University Medical Center
- Elena Carnero-Montoro
- Department of Epidemiology, Erasmus University Medical Center
- Jenny van Dongen
- Department of Biological Psychology, Amsterdam Public Health (APH) research institute, Amsterdam UMC, Vrije Universiteit Amsterdam
- Samantha Lent
- Department of Biostatistics, Boston University School of Public Health
- Ivana Nedeljkovic
- Department of Epidemiology, Erasmus University Medical Center
- Symen Ligthart
- Department of Epidemiology, Erasmus University Medical Center
- Pei-Chien Tsai
- Department of Twin Research and Genetic Epidemiology, King’s College London
- Tiphaine C. Martin
- Department of Twin Research and Genetic Epidemiology, King’s College London
- Pooja R. Mandaviya
- Department of Internal Medicine, Section of Pharmacology Vascular and Metabolic Diseases, Erasmus University Medical Center
- Rick Jansen
- Department of Psychiatry and Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam
- Marjolein J. Peters
- Department of Internal Medicine, Section of Pharmacology Vascular and Metabolic Diseases, Erasmus University Medical Center
- Liesbeth Duijts
- Division of Neonatology, Department of Pediatrics, Erasmus University Medical Center
- Vincent W. V. Jaddoe
- Department of Epidemiology, Erasmus University Medical Center
- Henning Tiemeier
- Department of Child and Adolescent Psychiatry, Erasmus University Medical Center
- Janine F. Felix
- Department of Epidemiology, Erasmus University Medical Center
- Gonneke Willemsen
- Department of Biological Psychology, Amsterdam Public Health (APH) research institute, Amsterdam UMC, Vrije Universiteit Amsterdam
- Eco J. C. de Geus
- Department of Biological Psychology, Amsterdam Public Health (APH) research institute, Amsterdam UMC, Vrije Universiteit Amsterdam
- Audrey Y. Chu
- The Population Sciences Branch, Division of Intramural Research, National Heart, Lung and Blood Institute, National Institutes of Health
- Daniel Levy
- The Population Sciences Branch, Division of Intramural Research, National Heart, Lung and Blood Institute, National Institutes of Health
- Shih-Jen Hwang
- The Population Sciences Branch, Division of Intramural Research, National Heart, Lung and Blood Institute, National Institutes of Health
- Jan Bressler
- Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston
- Rahul Gondalia
- Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina
- Elias L. Salfati
- Department of Medicine, Stanford University School of Medicine
- Christian Herder
- German Center for Diabetes Research (DZD)
- Bertha A. Hidalgo
- Department of Epidemiology, University of Alabama at Birmingham
- Toshiko Tanaka
- Translational Gerontology Branch, National Institute on Aging
- Ann Zenobia Moore
- Translational Gerontology Branch, National Institute on Aging
- Rozenn N. Lemaitre
- Cardiovascular Health Research Unit, Department of Medicine, University of Washington
- Min A Jhun
- Department of Epidemiology, School of Public Health, University of Michigan
- Jennifer A. Smith
- Department of Epidemiology, School of Public Health, University of Michigan
- Nona Sotoodehnia
- Cardiovascular Health Research Unit, Department of Medicine, University of Washington
- Stefania Bandinelli
- Geriatric Unit, Azienda Sanitaria di Firenze
- Luigi Ferrucci
- Translational Gerontology Branch, National Institute on Aging
- Donna K. Arnett
- School of Public Health, University of Kentucky
- Harald Grallert
- German Center for Diabetes Research (DZD)
- Themistocles L. Assimes
- Department of Medicine, Stanford University School of Medicine
- Lifang Hou
- Center for Population Epigenetics, Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University Chicago
- Andrea Baccarelli
- Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University
- Eric A. Whitsel
- Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina
- Ko Willems van Dijk
- Department of Human Genetics, Leiden University Medical Center
- Najaf Amin
- Department of Epidemiology, Erasmus University Medical Center
- André G. Uitterlinden
- Department of Epidemiology, Erasmus University Medical Center
- Eric J. G. Sijbrands
- Department of Internal Medicine, Section of Pharmacology Vascular and Metabolic Diseases, Erasmus University Medical Center
- Oscar H. Franco
- Department of Epidemiology, Erasmus University Medical Center
- Abbas Dehghan
- Department of Epidemiology, Erasmus University Medical Center
- Tim D. Spector
- Department of Twin Research and Genetic Epidemiology, King’s College London
- Josée Dupuis
- Department of Biostatistics, Boston University School of Public Health
- Marie-France Hivert
- Department of Medicine, Université de Sherbrooke
- Jerome I. Rotter
- The Institute for Translational Genomics and Population Sciences and Departments of Pediatrics and Medicine, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center
- James B. Meigs
- Department of Medicine, Harvard Medical School
- James S. Pankow
- Division of Epidemiology and Community Health, School of Public Health, University of Minnesota
- Joyce B. J. van Meurs
- CARIM School for Cardiovascular Diseases, Maastricht Centre for Systems Biology (MaCSBio), and Departments of Biochemistry and Physiology, Maastricht University
- Aaron Isaacs
- Department of Epidemiology, Erasmus University Medical Center
- Dorret I. Boomsma
- Department of Biological Psychology, Amsterdam Public Health (APH) research institute, Amsterdam UMC, Vrije Universiteit Amsterdam
- Jordana T. Bell
- Department of Twin Research and Genetic Epidemiology, King’s College London
- Ayşe Demirkan
- Department of Epidemiology, Erasmus University Medical Center
- Cornelia M. van Duijn
- Department of Epidemiology, Erasmus University Medical Center
- DOI
- https://doi.org/10.1038/s41467-019-10487-4
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 11
Abstract
Our understanding of the functional link between differential DNA methylation and type 2 diabetes and obesity remains limited. Here the authors present a blood-based EWAS of fasting glucose and insulin among 4808 non-diabetic Europeans and identify nine CpGs not previously implicated in glucose, insulin homeostasis and diabetes.
