Hepatitis C virus has a genetically determined lymphotropism through co-receptor B7.2

Chia-Lin Chen; Jeffrey Y. Huang; Chun-Hsiang Wang; Stanley M Tahara; Lin Zhou; Yasuteru Kondo; Joel Schechter; Lishan Su; Michael M C. Lai; Takaji Wakita; François-Loïc Cosset; Jae U Jung; Keigo Machida

doi:10.1038/ncomms13882

Nature Communications (Jan 2017)

Hepatitis C virus has a genetically determined lymphotropism through co-receptor B7.2

Chia-Lin Chen,
Jeffrey Y. Huang,
Chun-Hsiang Wang,
Stanley M Tahara,
Lin Zhou,
Yasuteru Kondo,
Joel Schechter,
Lishan Su,
Michael M C. Lai,
Takaji Wakita,
François-Loïc Cosset,
Jae U Jung,
Keigo Machida

Affiliations

Chia-Lin Chen: Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California
Jeffrey Y. Huang: Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California
Chun-Hsiang Wang: Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California
Stanley M Tahara: Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California
Lin Zhou: Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California
Yasuteru Kondo: Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California
Joel Schechter: Department of Cell and Neurobiology, Keck School of Medicine, University of Southern California
Lishan Su: Department of Microbiology and Immunology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
Michael M C. Lai: Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California
Takaji Wakita: Department of Virology II, National Institute of Infectious Diseases
François-Loïc Cosset: International Center for Infectiology Research, Team EVIR
Jae U Jung: Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California
Keigo Machida: Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California

DOI: https://doi.org/10.1038/ncomms13882
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 17

Abstract

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Infection of B cells by hepatitis C virus (HCV) is poorly understood, but is thought to result in lymphoproliferative disorders. Here, Chenet al. identify CD86 as co-receptor for lymphotropic HCV and show that HCV infection inhibits memory B-cell function.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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