The rhythmic coupling of Egr-1 and Cidea regulates age-related metabolic dysfunction in the liver of male mice

Jing Wu; Dandan Bu; Haiquan Wang; Di Shen; Danyang Chong; Tongyu Zhang; Weiwei Tao; Mengfei Zhao; Yue Zhao; Lei Fang; Peng Li; Bin Xue; Chao-Jun Li

doi:10.1038/s41467-023-36775-8

Nature Communications (Mar 2023)

The rhythmic coupling of Egr-1 and Cidea regulates age-related metabolic dysfunction in the liver of male mice

Jing Wu,
Dandan Bu,
Haiquan Wang,
Di Shen,
Danyang Chong,
Tongyu Zhang,
Weiwei Tao,
Mengfei Zhao,
Yue Zhao,
Lei Fang,
Peng Li,
Bin Xue,
Chao-Jun Li

Affiliations

Jing Wu: Ministry of Education Key Laboratory of Model Animal for Disease Study, Model Animal Research Center of the Medical School, Nanjing University
Dandan Bu: Ministry of Education Key Laboratory of Model Animal for Disease Study, Model Animal Research Center of the Medical School, Nanjing University
Haiquan Wang: Ministry of Education Key Laboratory of Model Animal for Disease Study, Model Animal Research Center of the Medical School, Nanjing University
Di Shen: Ministry of Education Key Laboratory of Model Animal for Disease Study, Model Animal Research Center of the Medical School, Nanjing University
Danyang Chong: Ministry of Education Key Laboratory of Model Animal for Disease Study, Model Animal Research Center of the Medical School, Nanjing University
Tongyu Zhang: Ministry of Education Key Laboratory of Model Animal for Disease Study, Model Animal Research Center of the Medical School, Nanjing University
Weiwei Tao: State Key Laboratory of Reproductive Medicine and China International Joint Research Center on Environment and Human Health, Center for Global Health, School of Public Health, Nanjing Medical University
Mengfei Zhao: Ministry of Education Key Laboratory of Model Animal for Disease Study, Model Animal Research Center of the Medical School, Nanjing University
Yue Zhao: Ministry of Education Key Laboratory of Model Animal for Disease Study, Model Animal Research Center of the Medical School, Nanjing University
Lei Fang: Ministry of Education Key Laboratory of Model Animal for Disease Study, Model Animal Research Center of the Medical School, Nanjing University
Peng Li: Institute of Metabolism & Integrative Biology (IMIB), Fudan University
Bin Xue: Core Laboratory, Sir Run Run Hospital, Nanjing Medical University
Chao-Jun Li: State Key Laboratory of Reproductive Medicine and China International Joint Research Center on Environment and Human Health, Center for Global Health, School of Public Health, Nanjing Medical University

DOI: https://doi.org/10.1038/s41467-023-36775-8
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 16

Abstract

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Many transcriptomic pathways in the liver show circadian rhythms, which have been reported to be disrupted in aged mice. Here the authors report that the expression of transcription factor Egr-1 decreases and its rhythm is shifted with age in the liver of male mice, and that deletion of Egr-1 results in increased liver fat accumulation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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