A Novel Role of Growth Differentiation Factor (GDF)-15 in Overlap with Sedentary Lifestyle and Cognitive Risk in COPD

Tsunahiko Hirano; Keiko Doi; Kazuto Matsunaga; Shun Takahashi; Tomohiro Donishi; Kazuyoshi Suga; Keiji Oishi; Kasumi Yasuda; Yusuke Mimura; Misa Harada; Sumiteru Suizu; Keita Murakawa; Ayumi Chikumoto; Yuichi Ohteru; Kazuki Matsuda; Sho Uehara; Kazuki Hamada; Shuichiro Ohata; Yoriyuki Murata; Yoshikazu Yamaji; Maki Asami-Noyama; Nobutaka Edakuni; Tomoyuki Kakugawa

doi:10.3390/jcm9092737

Journal of Clinical Medicine (Aug 2020)

A Novel Role of Growth Differentiation Factor (GDF)-15 in Overlap with Sedentary Lifestyle and Cognitive Risk in COPD

Tsunahiko Hirano,
Keiko Doi,
Kazuto Matsunaga,
Shun Takahashi,
Tomohiro Donishi,
Kazuyoshi Suga,
Keiji Oishi,
Kasumi Yasuda,
Yusuke Mimura,
Misa Harada,
Sumiteru Suizu,
Keita Murakawa,
Ayumi Chikumoto,
Yuichi Ohteru,
Kazuki Matsuda,
Sho Uehara,
Kazuki Hamada,
Shuichiro Ohata,
Yoriyuki Murata,
Yoshikazu Yamaji,
Maki Asami-Noyama,
Nobutaka Edakuni,
Tomoyuki Kakugawa

Affiliations

Tsunahiko Hirano: Department of Respiratory Medicine and Infectious Disease, Graduate School of Medicine, Yamaguchi University, Ube 755-8505, Japan
Keiko Doi: Department of Respiratory Medicine and Infectious Disease, Graduate School of Medicine, Yamaguchi University, Ube 755-8505, Japan
Kazuto Matsunaga: Department of Respiratory Medicine and Infectious Disease, Graduate School of Medicine, Yamaguchi University, Ube 755-8505, Japan
Shun Takahashi: Department of Neuropsychiatry, Wakayama Medical University, Wakayama 641-8510, Japan
Tomohiro Donishi: Department of System Neurophysiology, Graduate School of Wakayama Medical University, Wakayama 641-8510, Japan
Kazuyoshi Suga: Department of Radiology, Semui PET Screening and Radiatiotherapeutic Site, St. Hill Hospital, Ube 755-0155, Japan
Keiji Oishi: Department of Medicine and Clinical Science, Graduate School of Medicine, Yamaguchi University, Ube 755-8505, Japan
Kasumi Yasuda: Department of Neuropsychiatry, Wakayama Medical University, Wakayama 641-8510, Japan
Yusuke Mimura: Department of Clinical Research, National Hospital Organization Yamaguchi Ube Medical Center, Ube 755-0241, Japan
Misa Harada: Department of Respiratory Medicine and Infectious Disease, Graduate School of Medicine, Yamaguchi University, Ube 755-8505, Japan
Sumiteru Suizu: Department of Respiratory Medicine and Infectious Disease, Graduate School of Medicine, Yamaguchi University, Ube 755-8505, Japan
Keita Murakawa: Department of Respiratory Medicine and Infectious Disease, Graduate School of Medicine, Yamaguchi University, Ube 755-8505, Japan
Ayumi Chikumoto: Department of Respiratory Medicine and Infectious Disease, Graduate School of Medicine, Yamaguchi University, Ube 755-8505, Japan
Yuichi Ohteru: Department of Respiratory Medicine and Infectious Disease, Graduate School of Medicine, Yamaguchi University, Ube 755-8505, Japan
Kazuki Matsuda: Department of Respiratory Medicine and Infectious Disease, Graduate School of Medicine, Yamaguchi University, Ube 755-8505, Japan
Sho Uehara: Department of Respiratory Medicine and Infectious Disease, Graduate School of Medicine, Yamaguchi University, Ube 755-8505, Japan
Kazuki Hamada: Department of Respiratory Medicine and Infectious Disease, Graduate School of Medicine, Yamaguchi University, Ube 755-8505, Japan
Shuichiro Ohata: Department of Respiratory Medicine and Infectious Disease, Graduate School of Medicine, Yamaguchi University, Ube 755-8505, Japan
Yoriyuki Murata: Department of Medicine and Clinical Science, Graduate School of Medicine, Yamaguchi University, Ube 755-8505, Japan
Yoshikazu Yamaji: Department of Respiratory Medicine and Infectious Disease, Graduate School of Medicine, Yamaguchi University, Ube 755-8505, Japan
Maki Asami-Noyama: Department of Respiratory Medicine and Infectious Disease, Graduate School of Medicine, Yamaguchi University, Ube 755-8505, Japan
Nobutaka Edakuni: Department of Respiratory Medicine and Infectious Disease, Graduate School of Medicine, Yamaguchi University, Ube 755-8505, Japan
Tomoyuki Kakugawa: Department of Pulmonology and Gerontology Graduate School of Medicine, Yamaguchi University, Ube 755-8505, Japan

DOI: https://doi.org/10.3390/jcm9092737
Journal volume & issue: Vol. 9, no. 9
p. 2737

Abstract

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Sedentary behavior and cognitive impairment have a direct impact on patients’ outcomes. An energy metabolic disorder may be involved in the overlap of these comorbid conditions (motoric cognitive risk (MCR)) in patients with chronic obstructive pulmonary disease (COPD). We aimed to explore the linkage between a proapoptotic protein, growth differentiation factor (GDF)-15, and MCR. Physical activity (PA), cognitive function (Japanese version of the Montreal Cognitive Assessment: MOCA-J), and the serum GDF-15 levels were assessed in healthy subjects (n = 14), asthmatics (n = 22), and COPD patients (n = 28). In the entire cohort, serum GDF-15 had negative correlations with exercise (Ex) (ρ = −0.43, p ρ = −0.44, p ρ = 0.52, p < 0.0001). Compared to healthy subjects and asthmatics, COPD patients showed the highest serum GDF-15 levels and had a significantly higher proportion of subjects with MCR (both sedentary lifestyle (EX < 1.5) and cognitive risk (MoCA-J ≤ 25)). Also, we found that serum GDF-15 has a screening potential (100% sensitivity) greater than aging (67% sensitivity) for detecting MCR in COPD patients. In conclusion, higher serum GDF-15 had interrelationships with a sedentary lifestyle and cognitive risk. This protein was not disease-specific but could be a screening biomarker to detect MCR related to poor health outcomes of COPD patients.

Published in Journal of Clinical Medicine

ISSN: 2077-0383 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Medicine
Website: http://www.mdpi.com/journal/jcm

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