This review shows the influence of regional peculiarities in the distribution and frequency range of the human papillomavirus (HPV), which is necessary to predict the formation of malignant transformation of cervical epithelium, allocation risk of developing a malignant process, as well as for monitoring of HPV infection. Epidemiological studies on the prevalence of HPV allow to allocate the prevailing types of the virus and can serve as a basis for the creation of economically appropriate programs for the prevention and treatment of cervical cancer in different regions.