Optogenetic manipulation and photoacoustic imaging using a near-infrared transgenic mouse model

Ludmila A. Kasatkina; Chenshuo Ma; Mikhail E. Matlashov; Tri Vu; Mucong Li; Andrii A. Kaberniuk; Junjie Yao; Vladislav V. Verkhusha

doi:10.1038/s41467-022-30547-6

Nature Communications (May 2022)

Optogenetic manipulation and photoacoustic imaging using a near-infrared transgenic mouse model

Ludmila A. Kasatkina,
Chenshuo Ma,
Mikhail E. Matlashov,
Tri Vu,
Mucong Li,
Andrii A. Kaberniuk,
Junjie Yao,
Vladislav V. Verkhusha

Affiliations

Ludmila A. Kasatkina: Department of Genetics and Gruss-Lipper Biophotonics Center, Albert Einstein College of Medicine
Chenshuo Ma: Department of Biomedical Engineering, Duke University
Mikhail E. Matlashov: Department of Genetics and Gruss-Lipper Biophotonics Center, Albert Einstein College of Medicine
Tri Vu: Department of Biomedical Engineering, Duke University
Mucong Li: Department of Biomedical Engineering, Duke University
Andrii A. Kaberniuk: Department of Genetics and Gruss-Lipper Biophotonics Center, Albert Einstein College of Medicine
Junjie Yao: Department of Biomedical Engineering, Duke University
Vladislav V. Verkhusha: Department of Genetics and Gruss-Lipper Biophotonics Center, Albert Einstein College of Medicine

DOI: https://doi.org/10.1038/s41467-022-30547-6
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 16

Abstract

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Optogenetic tools can be used as in vivo imaging probes. Here the authors generate a loxP-BphP1 transgenic mouse to enable Cre-dependent temporal and spatial targeting of BphP1 expression in vivo; they show photoacoustic tomography of BphP1 expression in developing embryos and regenerating livers.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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