Nature Communications (Mar 2022)
An enhancer variant at 16q22.1 predisposes to hepatocellular carcinoma via regulating PRMT7 expression
- Ting Shen,
- Ting Ni,
- Jiaxuan Chen,
- Haitao Chen,
- Xiaopin Ma,
- Guangwen Cao,
- Tianzhi Wu,
- Haisheng Xie,
- Bin Zhou,
- Gang Wei,
- Hexige Saiyin,
- Suqin Shen,
- Peng Yu,
- Qianyi Xiao,
- Hui Liu,
- Yuzheng Gao,
- Xidai Long,
- Jianhua Yin,
- Yanfang Guo,
- Jiaxue Wu,
- Gong-Hong Wei,
- Jinlin Hou,
- De-Ke Jiang
Affiliations
- Ting Shen
- State Key Laboratory of Organ Failure Research, Guangdong Key Laboratory of Viral Hepatitis Research, Guangdong Institute of Liver Diseases, Department of Infectious Diseases and Hepatology Unit, Nanfang Hospital, Southern Medical University
- Ting Ni
- State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, Human Phenome Institute, School of Life Sciences, Fudan University
- Jiaxuan Chen
- State Key Laboratory of Organ Failure Research, Guangdong Key Laboratory of Viral Hepatitis Research, Guangdong Institute of Liver Diseases, Department of Infectious Diseases and Hepatology Unit, Nanfang Hospital, Southern Medical University
- Haitao Chen
- State Key Laboratory of Organ Failure Research, Guangdong Key Laboratory of Viral Hepatitis Research, Guangdong Institute of Liver Diseases, Department of Infectious Diseases and Hepatology Unit, Nanfang Hospital, Southern Medical University
- Xiaopin Ma
- State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, Human Phenome Institute, School of Life Sciences, Fudan University
- Guangwen Cao
- Department of Epidemiology, Naval Medical University
- Tianzhi Wu
- Institute of Bioinformatics, School of Basic Medical Science, Southern Medical University
- Haisheng Xie
- State Key Laboratory of Organ Failure Research, Guangdong Key Laboratory of Viral Hepatitis Research, Guangdong Institute of Liver Diseases, Department of Infectious Diseases and Hepatology Unit, Nanfang Hospital, Southern Medical University
- Bin Zhou
- State Key Laboratory of Organ Failure Research, Guangdong Key Laboratory of Viral Hepatitis Research, Guangdong Institute of Liver Diseases, Department of Infectious Diseases and Hepatology Unit, Nanfang Hospital, Southern Medical University
- Gang Wei
- State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, Human Phenome Institute, School of Life Sciences, Fudan University
- Hexige Saiyin
- State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, Human Phenome Institute, School of Life Sciences, Fudan University
- Suqin Shen
- State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, Human Phenome Institute, School of Life Sciences, Fudan University
- Peng Yu
- State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, Human Phenome Institute, School of Life Sciences, Fudan University
- Qianyi Xiao
- School of Public Health, Fudan University
- Hui Liu
- School of Basic Medical Sciences; The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People′s hospital, Guangzhou Medical University
- Yuzheng Gao
- Department of Forensic Medicine, Medical College of Soochow University
- Xidai Long
- Department of Pathology, Youjiang Medical College for Nationalities
- Jianhua Yin
- Department of Epidemiology, Naval Medical University
- Yanfang Guo
- Institute of Bioinformatics, School of Basic Medical Science, Southern Medical University
- Jiaxue Wu
- State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, Human Phenome Institute, School of Life Sciences, Fudan University
- Gong-Hong Wei
- Biocenter Oulu, Faculty of Biochemistry and Molecular Medicine, University of Oulu
- Jinlin Hou
- State Key Laboratory of Organ Failure Research, Guangdong Key Laboratory of Viral Hepatitis Research, Guangdong Institute of Liver Diseases, Department of Infectious Diseases and Hepatology Unit, Nanfang Hospital, Southern Medical University
- De-Ke Jiang
- State Key Laboratory of Organ Failure Research, Guangdong Key Laboratory of Viral Hepatitis Research, Guangdong Institute of Liver Diseases, Department of Infectious Diseases and Hepatology Unit, Nanfang Hospital, Southern Medical University
- DOI
- https://doi.org/10.1038/s41467-022-28861-0
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 15
Abstract
The role of enhancer variants in hepatocellular carcinoma (HCC) predisposition remains unknown. Here, the authors perform a genome-wide survey of HCC-susceptible enhancer variants in 11,958 individuals, identify rs73613962 within the intronic region of PRMT7 and find that PRMT7 upregulation predisposes to HCC.
