Molecules
(Sep 2022)
Synthesis of Potential Antiviral Agents for SARS-CoV-2 Using Molecular Hybridization Approach
Kailey A. Wyman,
Adel S. Girgis,
Pragnakiran S. Surapaneni,
Jade M. Moore,
Noura M. Abo Shama,
Sara H. Mahmoud,
Ahmed Mostafa,
Reham F. Barghash,
Zou Juan,
Radha D. Dobaria,
Ahmad J. Almalki,
Tarek S. Ibrahim,
Siva S. Panda
Affiliations
Kailey A. Wyman
Department of Chemistry and Physics, Augusta University, Augusta, GA 30912, USA
Adel S. Girgis
Department of Pesticide Chemistry, National Research Centre, Dokki, Giza 12622, Egypt
Pragnakiran S. Surapaneni
Department of Chemistry and Physics, Augusta University, Augusta, GA 30912, USA
Jade M. Moore
Department of Chemistry and Physics, Augusta University, Augusta, GA 30912, USA
Noura M. Abo Shama
Center of Scientific Excellence for Influenza Viruses, National Research Centre, Giza 12622, Egypt
Sara H. Mahmoud
Center of Scientific Excellence for Influenza Viruses, National Research Centre, Giza 12622, Egypt
Ahmed Mostafa
Center of Scientific Excellence for Influenza Viruses, National Research Centre, Giza 12622, Egypt
Reham F. Barghash
Department of Pesticide Chemistry, National Research Centre, Dokki, Giza 12622, Egypt
Zou Juan
Department of Chemistry and Physics, Augusta University, Augusta, GA 30912, USA
Radha D. Dobaria
Department of Chemistry and Physics, Augusta University, Augusta, GA 30912, USA
Ahmad J. Almalki
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia
Tarek S. Ibrahim
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia
Siva S. Panda
Department of Chemistry and Physics, Augusta University, Augusta, GA 30912, USA
DOI
https://doi.org/10.3390/molecules27185923
Journal volume & issue
Vol. 27,
no. 18
Abstract
Read online
We synthesized a set of small molecules using a molecular hybridization approach with good yields. The antiviral properties of the synthesized conjugates against the SAR-CoV-2 virus were investigated and their cytotoxicity was also determined. Among all the synthesized conjugates, compound 9f showed potential against SARS-CoV-2 and low cytotoxicity. The conjugates’ selectivity indexes (SIs) were determined to correlate the antiviral properties and cytotoxicity. The observed biological data were further validated using computational studies.
Keywords
WeChat QR code
Close
