Human growth hormone produced with recombinant DNA technology

Abstract

Hormones affect the metabolism by stimulating the genetic apparatus of the cell, activating enzymes and changing the rate of enzymatic reactions. They increase the formation of informative ribonucleic acid, which determines the structure of the protein, and affect the biosynthesis of proteins. Somatotropin hormone (STG) is a peptide hormone consisting of 192 amino acids and is secreted from the anterior lobe of the pituitary gland. The deficiency of this hormone causes hypophysis. The demand for recombinant somatotropin is likely to increase in the near future. Because current production technologies cannot meet the demand for cheap somatotropin due to limited production capacity and high production cost. As a result, it is necessary to study the mechanisms of production of therapeutic recombinant proteins. Recombinant somatotropin is mainly synthesized using E. coli lemo strain and is used for therapeutic purposes.