Functional compensation precedes recovery of tissue mass following acute liver injury

Chad M. Walesky; Kellie E. Kolb; Carolyn L. Winston; Jake Henderson; Benjamin Kruft; Ira Fleming; Sungjin Ko; Satdarshan P. Monga; Florian Mueller; Udayan Apte; Alex K. Shalek; Wolfram Goessling

doi:10.1038/s41467-020-19558-3

Nature Communications (Nov 2020)

Functional compensation precedes recovery of tissue mass following acute liver injury

Chad M. Walesky,
Kellie E. Kolb,
Carolyn L. Winston,
Jake Henderson,
Benjamin Kruft,
Ira Fleming,
Sungjin Ko,
Satdarshan P. Monga,
Florian Mueller,
Udayan Apte,
Alex K. Shalek,
Wolfram Goessling

Affiliations

Chad M. Walesky: Genetics Division, Brigham and Women’s Hospital, Harvard Medical School
Kellie E. Kolb: Institute of Medical Engineering & Science (IMES), Department of Chemistry, and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
Carolyn L. Winston: Genetics Division, Brigham and Women’s Hospital, Harvard Medical School
Jake Henderson: Genetics Division, Brigham and Women’s Hospital, Harvard Medical School
Benjamin Kruft: Genetics Division, Brigham and Women’s Hospital, Harvard Medical School
Ira Fleming: Institute of Medical Engineering & Science (IMES), Department of Chemistry, and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
Sungjin Ko: Department of Pathology, University of Pittsburgh, School of Medicine; and Pittsburgh Liver Research Center, University of Pittsburgh and University of Pittsburgh Medical Center
Satdarshan P. Monga: Department of Pathology, University of Pittsburgh, School of Medicine; and Pittsburgh Liver Research Center, University of Pittsburgh and University of Pittsburgh Medical Center
Florian Mueller: Imaging and Modeling Unit, Institut Pasteur, UMR 3691CNRS, C3BI USR 3756 IP CNRS
Udayan Apte: Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center
Alex K. Shalek: Institute of Medical Engineering & Science (IMES), Department of Chemistry, and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
Wolfram Goessling: Genetics Division, Brigham and Women’s Hospital, Harvard Medical School

DOI: https://doi.org/10.1038/s41467-020-19558-3
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 12

Abstract

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The liver possesses the ability to regenerate following sudden injury. Here, the authors use single-cell RNA-sequencing and in situ transcriptional analyses to identify a new phase of liver regeneration in mice aimed at maintaining essential functions throughout the regenerative process.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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