The effects of metabolites from three vaginal bacteria on the Syndecan-1 of cervical epithelial cells

Yan Xia; Ying Feng; Lan Jiang; Youqiang Heng; Xiaoqin Li; Cailing Ma

Heliyon (Jun 2024)

The effects of metabolites from three vaginal bacteria on the Syndecan-1 of cervical epithelial cells

Yan Xia,
Ying Feng,
Lan Jiang,
Youqiang Heng,
Xiaoqin Li,
Cailing Ma

Affiliations

Yan Xia: Department of Assisted Reproduction, Urumqi Maternal and Child Health Hospital, Urumqi, 830000, China; Department of Gynecology, The First Affiliated Hospital of Xinjiang Medical University, State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Urumqi, 830000, China
Ying Feng: Department of Assisted Reproduction, Urumqi Maternal and Child Health Hospital, Urumqi, 830000, China
Lan Jiang: Department of Laboratory Medicine, Urumqi Maternal and Child Health Hospital, Urumqi, 830000, China
Youqiang Heng: Department of Gynecology, The First Affiliated Hospital of Xinjiang Medical University, State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Urumqi, 830000, China; Xinjiang Key Laboratory of Medical Animal Model Research, Urumqi, 830000, China
Xiaoqin Li: Department of Laboratory Medicine, Urumqi Maternal and Child Health Hospital, Urumqi, 830000, China
Cailing Ma: Department of Gynecology, The First Affiliated Hospital of Xinjiang Medical University, State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Urumqi, 830000, China; Xinjiang Key Laboratory of Medical Animal Model Research, Urumqi, 830000, China; Corresponding author. Department of Gynecology, The First Affiliated Hospital of Xinjiang Medical University, State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, No. 137 Liyushan South Road, Xinshi District, Urumqi, 830000, China.

Journal volume & issue: Vol. 10, no. 12
p. e33426

Abstract

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This study aims to explore the impact of metabolites from three vaginal bacteria on the expression of Syndecan 1 (SDC-1). Human cervical epithelial cells (HcerEpic) were separately incubated with the cell-free supernatants of Lactobacillus crispatus (LCS group), Gardnerella vaginalis (GVS group), and Atopobium vaginalis (AVS group). LCS showed a proliferative effect on HcerEpic, with the most significant effect observed at a concentration of 30 % (P 0.05). LCS promotes HcerEpic proliferation, without significant impact on SDC-1 expression and shedding. This provides molecular evidence for LCS as a protective factor against human papillomavirus infection in the cervix. Metabolites of GV and AV inhibit HcerEpic proliferation, induce cytokine secretion, suppress SDC-1 transcription and expression, and promote SDC-1 shedding.

Published in Heliyon

ISSN: 2405-8440 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Science: Science (General); Social Sciences: Social sciences (General)
Website: https://www.cell.com/heliyon/home

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