Intranasal delivery of pro-resolving lipid mediators rescues memory and gamma oscillation impairment in App NL-G-F/NL-G-F mice

Ceren Emre; Luis E. Arroyo-García; Khanh V. Do; Bokkyoo Jun; Makiko Ohshima; Silvia Gómez Alcalde; Megan L. Cothern; Silvia Maioli; Per Nilsson; Erik Hjorth; André Fisahn; Nicolas G. Bazan; Marianne Schultzberg

doi:10.1038/s42003-022-03169-3

Communications Biology (Mar 2022)

Intranasal delivery of pro-resolving lipid mediators rescues memory and gamma oscillation impairment in App NL-G-F/NL-G-F mice

Ceren Emre,
Luis E. Arroyo-García,
Khanh V. Do,
Bokkyoo Jun,
Makiko Ohshima,
Silvia Gómez Alcalde,
Megan L. Cothern,
Silvia Maioli,
Per Nilsson,
Erik Hjorth,
André Fisahn,
Nicolas G. Bazan,
Marianne Schultzberg

Affiliations

Ceren Emre: Department of Neurobiology, Care Sciences and Society, Division of Neurogeriatrics, Center for Alzheimer Research, Karolinska Institutet
Luis E. Arroyo-García: Department of Neurobiology, Care Sciences and Society, Division of Neurogeriatrics, Center for Alzheimer Research, Karolinska Institutet
Khanh V. Do: Neuroscience Center of Excellence, School of Medicine, Louisiana State University Health New Orleans
Bokkyoo Jun: Neuroscience Center of Excellence, School of Medicine, Louisiana State University Health New Orleans
Makiko Ohshima: Department of Neurobiology, Care Sciences and Society, Division of Neurogeriatrics, Center for Alzheimer Research, Karolinska Institutet
Silvia Gómez Alcalde: Department of Neurobiology, Care Sciences and Society, Division of Neurogeriatrics, Center for Alzheimer Research, Karolinska Institutet
Megan L. Cothern: Neuroscience Center of Excellence, School of Medicine, Louisiana State University Health New Orleans
Silvia Maioli: Department of Neurobiology, Care Sciences and Society, Division of Neurogeriatrics, Center for Alzheimer Research, Karolinska Institutet
Per Nilsson: Department of Neurobiology, Care Sciences and Society, Division of Neurogeriatrics, Center for Alzheimer Research, Karolinska Institutet
Erik Hjorth: Department of Neurobiology, Care Sciences and Society, Division of Neurogeriatrics, Center for Alzheimer Research, Karolinska Institutet
André Fisahn: Department of Neurobiology, Care Sciences and Society, Division of Neurogeriatrics, Center for Alzheimer Research, Karolinska Institutet
Nicolas G. Bazan: Neuroscience Center of Excellence, School of Medicine, Louisiana State University Health New Orleans
Marianne Schultzberg: Department of Neurobiology, Care Sciences and Society, Division of Neurogeriatrics, Center for Alzheimer Research, Karolinska Institutet

DOI: https://doi.org/10.1038/s42003-022-03169-3
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 15

Abstract

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Intranasal administration of pro-resolving lipid mediators improves memory deficits and reduce microglial activation in a mouse model for Alzheimer’s disease, suggesting a future therapy.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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