A differential equations model-fitting analysis of COVID-19 epidemiological data to explain multi-wave dynamics

Abstract

Abstract Compartmental epidemiological models are, by far, the most popular in the study of dynamics related with infectious diseases. It is, therefore, not surprising that they are frequently used to study the current COVID-19 pandemic. Taking advantage of the real-time availability of COVID-19 related data, we perform a compartmental model fitting analysis of the portuguese case, using an online open-access platform with the integrated capability of solving systems of differential equations. This analysis enabled the data-driven validation of the used model and was the basis for robust projections of different future scenarios, namely, increasing the detected infected population, reopening schools at different moments, allowing Easter celebrations to take place and population vaccination. The method presented in this work can easily be used to perform the non-trivial task of simultaneously fitting differential equation solutions to different epidemiological data sets, regardless of the model or country that might be considered in the analysis.