Follicular graft-versus-host disease: A rare manifestation in a patient with the overlap subtype of chronic graft-versus-host disease

Abstract

Graft-versus-host disease (GVHD) is a frequent and potentially life-threatening complication of hematopoietic stem cell transplantation (HSCT). Although skin involvement is common, generalized follicular eruption as the major clinical manifestation is rare. However, it is important for clinicians to recognize it at the earliest to initiate an appropriate therapy. We report a case of a patient with multiple myeloma who developed extensive hyperkeratotic, lichenoid folliculocentric papules with perifollicular erythema on day 53 following an allogeneic HSCT. The overall clinical and histological findings were consistent with the overlap subtype of chronic follicular GVHD.

Keywords

• Allogeneic hematopoietic stem cell transplantation
• follicular graft-versus-host disease
• overlap subtype