Frontiers in Cell and Developmental Biology (Jul 2022)

Application of Cell-Derived Extracellular Vesicles and Engineered Nanovesicles for Hair Growth: From Mechanisms to Therapeutics

  • Prakash Gangadaran,
  • Prakash Gangadaran,
  • Ramya Lakshmi Rajendran,
  • Mi Hee Kwack,
  • Mi Hee Kwack,
  • Madhan Jeyaraman,
  • Madhan Jeyaraman,
  • Madhan Jeyaraman,
  • Chae Moon Hong,
  • Chae Moon Hong,
  • Young Kwan Sung,
  • Young Kwan Sung,
  • Byeong-Cheol Ahn,
  • Byeong-Cheol Ahn,
  • Byeong-Cheol Ahn

DOI
https://doi.org/10.3389/fcell.2022.963278
Journal volume & issue
Vol. 10

Abstract

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Hair loss is one of the most common disorders that affect both male and female patients. Cell-derived nanovesicles (CDVs) are natural extracellular vesicles and engineered nanovesicles that can carry various biologicals materials such as proteins, lipids, mRNA, miRNA, and DNA. These vesicles can communicate with local or distant cells and are capable of delivering endogenous materials and exogenous drugs for regenerative therapies. Recent studies revealed that CDVs can serve as new treatment strategies for hair growth. Herein, we review current knowledge on the role of CDVs in applications to hair growth. The in-depth understanding of the mechanisms by which CDVs enable therapeutic effects for hair growth may accelerate successful clinical translation of these vesicles for treating hair loss.

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