Self-gelation techniques for amoxicillin: formulation and characterization

Abstract

Self-assembled hydrogels without structural alterations have been a topic of considerable interest. Here, a novel self-assembled amoxicillin hydrogel devoid of any gelling substances or structural modifications was formulated with high stability. The minimum gelator concentration (MGC) was 7.14 wt.% and the gel dissociation temperature (Tgel) was found to be 43.1 °C. The formulated gel was further characterized using FE-SEM, 1H NMR, FT-IR, XRD, rheology, and contact angle measurements, which provided strong evidence in favor of the formation of hydrogel. Furthermore, computational study of gel network formation and kinetic study of amoxicillin release found that the gel exhibited an excellent release rate.

Keywords

• Amoxicillin
• Gels
• Self-assembled gel
• Supramolecular chemistry
• Pharmacokinetics