Longitudinal patient-reported outcomes 1 year after thoracoscopic segmentectomy versus lobectomy for early-stage lung cancer: a multicentre, prospective cohort study protocol
Rong Zhang,
Xin Gao,
Qi Zhang,
Wei Dai,
Bo Tian,
Qiang Li,
Dan Chen,
Xiang Wang,
Yu He,
Shaohua Xie,
Qiuling Shi,
Xing Wei,
Xiaojun Yang,
Shan Gao,
Bin Hu,
Yong Tang,
Nan Sun,
Yue Cui,
Yangjun Liu,
Yang Pu,
Xiaobo Chen,
Wenwu Liu,
Lingjia Yang,
Cecilia Pompili,
Run Xiang,
Xiaozun Yang,
Tianpeng Xie,
Guibin Qiao,
Guangjian Zhang,
Xiang Zhuang
Affiliations
Rong Zhang
Clinical Laboratory Medicine, The Second Affiliated Hospital of Zhejiang University, Zhejiang University, Hangzhou, China
Xin Gao
The Second Clinical Medical College of Lanzhou University, Lanzhou, Gansu, China
Qi Zhang
Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, People`s Republic of China
Wei Dai
Department of Thoracic Surgery, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China
Bo Tian
4 Department of Thoracic Surgery, Beijing Chao-yang Hospital, Capital Medical University, Beijing, China
Qiang Li
1 Department of Cerebrovascular Disease, Henan Provincial People`s Hospital, Zhengzhou, Henan, China
Dan Chen
1 Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Ministry of Education-Shanghai Key Laboratory of Children’s Environmental Health, Shanghai, China
Xiang Wang
Department of Neurology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China
Yu He
Department of Rehabilitation, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China
Shaohua Xie
1 Department of Thoracic Surgery, Sichuan Cancer Hospital and Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China
Qiuling Shi
Center for Cancer Prevention Research, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China
Xing Wei
Department of Thoracic Surgery, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China
Xiaojun Yang
1 Department of Thoracic Surgery, Sichuan Cancer Hospital and Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China
Shan Gao
Department of Infection Control, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan, China
Bin Hu
11 Department of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
Yong Tang
Arena Pharmaceuticals, Inc., San Diego, USA
Nan Sun
2 Division of Diagnostic for Non-infectious Disease, National Institutes for Food and Drug Control, Beijing, China
Yue Cui
Department of Neurology, Xuanwu hospital,Capital Medical University, Beijing, People`s Republic of China
Yangjun Liu
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
Yang Pu
School of Public Health, Chongqing Medical University, Chongqing, China
Xiaobo Chen
doctor in dentistry
Wenwu Liu
Department of Thoracic Surgery, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, University of Electronic Science and Technology of China, Chengdu, Sichuan, China
Lingjia Yang
College of Medical and Dental Science, University of Birmingham, Birmingham, UK
Cecilia Pompili
Thoracic Surgery Unit, University and Hospital Trust - Ospedale Borgo Trento, Verona, Italy
Run Xiang
Department of Thoracic Surgery, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, University of Electronic Science and Technology of China, Chengdu, Sichuan, China
Xiaozun Yang
Department of Thoracic Surgery, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, University of Electronic Science and Technology of China, Chengdu, Sichuan, China
Tianpeng Xie
Department of Thoracic Surgery, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, University of Electronic Science and Technology of China, Chengdu, Sichuan, China
Guibin Qiao
Department of Thoracic Surgery, Guangdong Provincial People`s Hospital, Guangzhou, Guangdong, China
Guangjian Zhang
Department of Thoracic Surgery, The First Affiliated Hospital of Xi`an Jiaotong University, Xi`an, Shaanxi, China
Xiang Zhuang
Department of Thoracic Surgery, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, University of Electronic Science and Technology of China, Chengdu, Sichuan, China
Introduction Segmentectomy and lobectomy are the main surgical procedures for early-stage lung cancer. However, few studies have analysed patient-reported outcomes after segmentectomy versus lobectomy. This study aims to compare patient-reported outcomes—such as symptoms, daily functioning and quality of life—between thoracoscopic segmentectomy and lobectomy for early-stage lung cancer during the 1 year after surgery.Methods and analysis Overall, 788 newly diagnosed patients with early-stage lung cancer (tumour size ≤2 cm), who are scheduled to undergo thoracoscopic segmentectomy or lobectomy, will be recruited in this multicentre, prospective cohort study. The patients will receive standardised care after surgery. The Perioperative Symptom Assessment for Lung Surgery—a validated lung cancer surgery-specific scale—will be used to assess the symptoms and functions at baseline, at discharge and monthly after discharge for 1 year. The European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 and Lung Cancer module 29 will be used to assess the patients’ quality of life at the same time points. The primary outcome will be the shortness of breath scores during the first year after thoracoscopic segmentectomy and lobectomy and will be compared using mixed-effects models. The secondary outcomes will include other symptoms, indicators of daily functioning, quality of life scores and traditional clinical outcomes. These will be compared using mixed-effects models and the Student’s t-test, non-parametric test or Χ2 test. Propensity score matching will be used to ensure an even distribution of known confounders between the groups.Ethics and dissemination The Ethics Committee for Medical Research and New Medical Technology of Sichuan Cancer Hospital approved this study (approval number: SCCHEC-02-2022-002). All participants will be instructed to provide informed consent. The manuscript is based on protocol version 3.0. The study results will be presented at medical conferences and published in peer-reviewed journals.Trial registration number ChiCTR2200060753.
