Periodontal Disease-Induced Atherosclerosis and Oxidative Stress
Tomoko Kurita-Ochiai,
Ru Jia,
Yu Cai,
Yohei Yamaguchi,
Masafumi Yamamoto
Affiliations
Tomoko Kurita-Ochiai
Department of Microbiology and Immunology, Nihon University School of Dentistry at Matsudo, Chiba 271-8587, Japan
Ru Jia
Stomatology Hospital, Tongji University, Shanghai 200072, China
Yu Cai
Department of Periodontology, Peking University School and Hospital of Stomatology, 22 Zhongguancun Avenue South, Haidian District, Beijing 100081, China
Yohei Yamaguchi
Department of Oral and Maxillofacial Surgery, School of Medicine, Tokyo Women's Medical University, Tokyo 162-8666, Japan
Masafumi Yamamoto
Department of Microbiology and Immunology, Nihon University School of Dentistry at Matsudo, Chiba 271-8587, Japan
Periodontal disease is a highly prevalent disorder affecting up to 80% of the global population. Recent epidemiological studies have shown an association between periodontal disease and cardiovascular disease, as oxidative stress plays an important role in chronic inflammatory diseases such as periodontal disease and cardiovascular disease. In this review, we focus on the mechanisms by which periodontopathic bacteria cause chronic inflammation through the enhancement of oxidative stress and accelerate cardiovascular disease. Furthermore, we comment on the antioxidative activity of catechin in atherosclerosis accelerated by periodontitis.
