RAGA prevents tumor immune evasion of LUAD by promoting CD47 lysosome degradation

Lian Zhang; Jing Yu; Mingyue Zheng; Hui Zhen; Qingqiang Xie; Chundong Zhang; Zhongjun Zhou; Guoxiang Jin

doi:10.1038/s42003-023-04581-z

Communications Biology (Feb 2023)

RAGA prevents tumor immune evasion of LUAD by promoting CD47 lysosome degradation

Lian Zhang,
Jing Yu,
Mingyue Zheng,
Hui Zhen,
Qingqiang Xie,
Chundong Zhang,
Zhongjun Zhou,
Guoxiang Jin

Affiliations

Lian Zhang: Medical Research Institute, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University
Jing Yu: Department of Surgery Oncology, The Second People’s Hospital of Neijiang
Mingyue Zheng: Medical Research Institute, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University
Hui Zhen: Medical Research Institute, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University
Qingqiang Xie: Medical Research Institute, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University
Chundong Zhang: Department of Biochemistry and Molecular Biology, Chongqing Medical University
Zhongjun Zhou: School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, University of Hong Kong
Guoxiang Jin: Medical Research Institute, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University

DOI: https://doi.org/10.1038/s42003-023-04581-z
Journal volume & issue: Vol. 6, no. 1
pp. 1 – 12

Abstract

Read online

The lysosome protein RAGA interacts with and promotes lysosome localization and degradation of the macrophage-specific immune checkpoint protein CD47, with possible relevance to lung adenocarcinoma

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal