Nature Communications (Dec 2017)

Alternative activation generates IL-10 producing type 2 innate lymphoid cells

  • Corey R. Seehus,
  • Asha Kadavallore,
  • Brian de la Torre,
  • Alyson R. Yeckes,
  • Yizhou Wang,
  • Jie Tang,
  • Jonathan Kaye

DOI
https://doi.org/10.1038/s41467-017-02023-z
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 13

Abstract

Read online

Type 2 innate lymphoid cells (ILC2) are thought to be a uniform population of effector cells that produce IL-5 and IL-13. Here, the authors shown that, in mice, IL-33 can alternatively activate these cells to generate a molecularly distinct IL-10-producing subset designated ILC210.