Journal of Nutrition and Metabolism (Jan 2018)

The Hepatoprotective Effect of Jaboticaba Peel Powder in a Rat Model of Type 2 Diabetes Mellitus Involves the Modulation of Thiol/Disulfide Redox State through the Upregulation of Glutathione Synthesis

  • Andréia Quatrin,
  • Lisiane Conte,
  • Dariane Trivisiol da Silva,
  • Cassieli Gehlen Figueiredo,
  • Sabrina Somacal,
  • Miguel Roehrs,
  • Cibele Ferreira Teixeira,
  • Fernanda Barbisan,
  • Paula Rossini Augusti,
  • Mário Roberto Maróstica Júnior,
  • Ivana Beatrice Mânica da Cruz,
  • Tatiana Emanuelli

DOI
https://doi.org/10.1155/2018/9794629
Journal volume & issue
Vol. 2018

Abstract

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Jaboticaba peel powder (JPP) is rich in bioactive compounds, mainly soluble and insoluble polyphenols with great antioxidant properties. The aim of this study is to evaluate the effects of JPP supplementation on the oxidative stress and hepatic damage in a rat model of type 2 diabetes mellitus (T2DM). Diabetic rats received vehicle or JPP at 2.7 (JPP-I), 5.4 (JPP-II), or 10.8 (JPP-III) g/L in drinking water during 8 weeks. JPP-III attenuated hyperglycaemia and dyslipidemia increased by 86% the liver content of nonprotein thiol groups and by 90% the GSH/GSSG ratio by activating glutathione synthesis. Accordingly, JPP supplementation prevented the loss of activity of the sulfhydryl-dependent enzyme δ-aminolaevulinic acid dehydratase and attenuated hepatic injury assessed by the reduction of serum aspartate aminotransferase activity and liver hypertrophy. Our results support that JPP supplementation to T2DM rats decreases hepatic damage most likely by increasing glutathione synthesis and modulating the thiol/disulfide redox balance.