Рациональная фармакотерапия в кардиологии (Jan 2016)

COMPARATIVE EFFICACY OF THE STATINS IN PREVENTING AND TREATING OF THE CORONARY HEART DISEASE

  • S. V. Shalaev,
  • Z. M. Safiullina,
  • L. V. Kremneva,
  • O. V. Abaturova

DOI
https://doi.org/10.20996/1819-6446-2010-6-6-865-869
Journal volume & issue
Vol. 6, no. 6
pp. 865 – 869

Abstract

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The possibility to stabilize and reverse the atherosclerotic plaques in coronary arteries due to therapy with atorvastatin and rosuvastatin was demonstrated in recent studies. The advantage of aggressive lipid-lowering therapy compared with standard therapy is proven in patients with both stable and acute forms of ischemic heart disease (IHD). Pleiotropic effects, in particular, effect on endothelial function, ability to reduce the blood level of C-reactive protein are important in the statins mode of action. Risk reduction of cardiovascular complications and slow down of atherosclerosis progression in patients with IHD was significantly associated with decrease in levels of both atherogenic lipids and C-reactive protein.

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